N Turner, CR Bruce, SM Beale, KL Hoehn, T So, MS … - Diabetes, 2007 - Am Diabetes Assoc A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been proposed
as a major factor leading to the accumulation of intramuscular lipids and their subsequent deleterious
effects on insulin action. Here, we examine markers of mitochondrial fatty acid oxidative ... Cited by 63 - Related articles - BL Direct - All 5 versions
LA Lesniewski, SE Hosch, JG Neels, C de Luca, M … - Nature medicine, 2007 - nature.com Cbl-associated protein (Cap) is a member of a phosphatidylinositol 3-kinase–independent pathway
for insulin-stimulated translocation of the glucose transporter GLUT4. Despite this positive role
of Cap in glucose uptake, here we show that deletion of the gene encoding Cap (official ... Cited by 25 - Related articles - BL Direct - All 6 versions
PO Prada, JR Pauli, ER Ropelle, HG Zecchin, JBC … - FEBS letters, 2006 - Elsevier A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose
tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in
adipose tissue by increasing signal transduction through the CAP/Cbl pathway, ... Cited by 12 - Related articles - All 7 versions
- ►diabetesjournals.org JC Molero, N Turner, CBF Thien, WY Langdon, DE … - Diabetes, 2006 - Am Diabetes Assoc Casitas b-lineage lymphoma (c-Cbl) is a multiadaptor protein with E3-ubiquitin ligase activity
residing within its RING finger domain. We have previously reported that c-Cbl–deficient mice
exhibit elevated energy expenditure, reduced adiposity, and improved insulin action. In ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►physiology.org HA Parkes, E Preston, D Wilks, M … - American Journal of …, 2006 - Am Physiological Soc Accumulation of intracellular lipid in obesity is associated with metabolic disease in many tissues
including liver. Storage of fatty acid as triglyceride (TG) requires the activation of fatty acids to
long-chain acyl-CoAs (LC-CoA) by the enzyme acyl-CoA synthetase (ACSL). There are ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org PF Pilch, N Bergenhem - Molecular pharmacology, 2006 - ASPET The incidence of obesity is increasing dramatically to epidemic proportions in virtually all societies
of the world (Flier, 2004 Go ), and with it come the major pathological consequences of type 2
diabetes and cardiovascular disease as well as other less common pathologies. From a ... Cited by 5 - Related articles - BL Direct - All 7 versions
S Wing - BMC biochemistry, 2008 - biomedcentral.com Type 2 diabetes is caused by defects in both insulin signaling and insulin secretion. Though
the role of the ubiquitin proteasome system (UPS) in the pathogenesis of type 2 diabetes remains
largely unexplored, the few examples present in the literature are interesting and suggest ... Cited by 2 - Related articles - Cached - All 6 versions
H Li, LK Heilbronn, D Hu, AM Poynten, MA Blackburn, … - Obesity, 2008 - nature.com Objective: Adiponectin is the most abundant protein secreted by adipose tissue and is inversely
associated with adiposity and insulin resistance. The aim of this study was to evaluate the hypothesis
that marked weight loss, induced by gastric bypass surgery (GBS), would increase ... Cited by 1 - Related articles - All 2 versions
L Zhang, L Macia, N Turner, RF Enriquez, SJ … - International Journal of …, 2009 - nature.com Neuropeptide Y and its Y receptors are important players in the regulation of energy
homeostasis. However, while their functions in feeding regulation are well recognized, functions
in other critical aspects of energy homeostasis are largely unknown. To investigate the ...
AJ Hoy, AE Brandon, N Turner, MJ Watt, … - American Journal of …, 2009 - Am Physiological Soc Type 2 diabetes is characterized by hyperlipidemia, hyperinsulinemia, and insulin
resistance. The aim of this study was to investigate whether acute hyperlipidemia-induced insulin
resistance in the presence of hyperinsulinemia was due to defective insulin signaling. ... Related articles - All 2 versions
