ARA Alabi, MI Bahamonde, HJ Jung, JI Kim, KJ Swartz - Nature, 2007 - pubmedcentral.nih.gov Voltage-sensing domains enable membrane proteins to sense and react to changes in membrane
voltage. Although identifiable S1–S4 voltage-sensing domains are found in an array of conventional
ion channels and in other membrane proteins that lack pore domains, the extent to which ... Cited by 34 - Related articles - BL Direct - All 6 versions
- ►nih.gov KJ Swartz - Toxicon, 2007 - Elsevier Voltage-activated ion channels open and close in response to changes in membrane
voltage, a process that is crucial for electrical signaling in the nervous system. The venom from
many poisonous creatures contains a diverse array of small protein toxins that bind to ... Cited by 20 - Related articles - All 6 versions
- ►diabetesjournals.org CP Tan, Y Feng, YP Zhou, GJ Eiermann, A Petrov, C … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free fatty acids
(FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter of
debate whether activation of GPR40 would be beneficial for the treatment of type 2 ... Cited by 17 - Related articles - All 5 versions
K Dezaki, M Kakei, T Yada - Diabetes, 2007 - Am Diabetes Assoc Ghrelin reportedly serves as a physiological regulator of insulin release. This study aimed to
explore signaling mechanisms for insulinostatic ghrelin action in islet β-cells, with special attention
to heterotrimeric GTP-binding proteins and K + channels. Plasma insulin and growth ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►endojournals.org YM Leung, EP Kwan, B Ng, Y Kang, HY Gaisano - Endocrine reviews, 2007 - Endocrine Soc The three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor)
proteins, syntaxin, SNAP25 (synaptosome-associated protein of 25 kDa), and
synaptobrevin, constitute the minimal machinery for exocytosis in secretory cells such as ... Cited by 16 - Related articles - BL Direct - All 3 versions
M Braun, R Ramracheya, M Bengtsson, Q Zhang, J … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Human β-cells express two types of voltage-gated K + currents that flow through
delayed rectifying (K V 2.1/2.2) and large-conductance Ca 2+ -activated K + (BK) channels. Blockade
of BK channels (using iberiotoxin) increased action potential amplitude and enhanced ... Cited by 14 - Related articles - All 5 versions
- ►nih.gov A Scholle, T Zimmer, R Koopmann, B Engeland, O … - Biophysical journal, 2004 - Elsevier Depolarizing voltage steps activate voltage-dependent K + (Kv) channels by moving the voltage
sensor, which triggers a coupling reaction leading to the opening of the pore. We constructed
chimeric channels in which intracellular regions of slowly activating Kv2.1 channels were ... Cited by 13 - Related articles - BL Direct - All 11 versions
F Bosmans, MF Martin-Eauclaire, KJ Swartz - Nature, 2008 - pubmedcentral.nih.gov Voltage-activated sodium (Nav) channels are crucial for the generation and propagation of nerve
impulses, and as such are amongst the most widely targeted ion channels by toxins and
drugs. The four voltage sensors in Nav channels have distinct amino acid sequences, ... Cited by 11 - Related articles - All 9 versions
- ►nih.gov DA Jacobson, A Kuznetsov, JP Lopez, S Kash, CE … - Cell metabolism, 2007 - Elsevier Voltage-gated potassium currents (Kv), primarily due to Kv2.1 channels, are activated by
glucose-stimulated pancreatic β cell depolarization, but the exact role (or roles) of this channel
in regulating insulin secretion remains uncertain. Here we report that, compared with ... Cited by 7 - Related articles - All 5 versions
