- ►physiology.org LE Parton, PJ McMillen, Y Shen, E Docherty, E … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Accumulation of intracellular lipid may contribute to defective insulin
secretion in type 2 diabetes. Although Zucker diabetic fatty (ZDF; fa/fa) rat
islets are fat-laden and overexpress the lipogenic master gene, sterol ... Cited by 17 - Related articles - BL Direct - All 3 versions
PE MacDonald, P Rorsman - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is
crucial to maintenance of plasma glucose levels. They fuse with the plasma
membrane in a regulated manner to release their contents and are ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►cell.com DJ Michael, H Cai, W Xiong, J Ouyang, RH … - Trends in Endocrinology & Metabolism, 2006 - Elsevier According to the classical view, peptide hormones are stored in large dense-core
vesicles that release all of their cargo rapidly and completely when they fuse
with and flatten into the plasma membrane. However, recent imaging studies ... Cited by 13 - Related articles - All 4 versions
- ►shouxi.net CS Olofsson, S Collins, M Bengtsson, L … - Diabetes, 2007 - Am Diabetes Assoc Mouse β-cells cultured at 15 mmol/l glucose for 72 h had reduced ATP-sensitive
K + (K ATP ) channel activity (−30%), increased voltage-gated Ca 2+ currents,
higher intracellular free Ca 2+ concentration ([Ca 2+ ] i ; +160%), more ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►rupress.org T Rose, S Efendic, M Rupnik - Journal of General Physiology, 2007 - jgp.rupress.org The Goto Kakizaki (GK) rat is a widely used animal model to study defective
glucose-stimulated insulin release in type-2 diabetes (T2D). As in T2D patients,
the expression of several proteins involved in Ca 2+ -dependent exocytosis ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►nih.gov L Eliasson, F Abdulkader, M Braun, J … - The Journal of Physiology, 2008 - Physiological Soc Pancreatic β-cells secrete insulin by Ca 2+ -dependent exocytosis of secretory
granules. β-cell exocytosis involves SNARE (soluble NSF-attachment protein
receptor) proteins similar to those controlling neurotransmitter release ... Cited by 8 - Related articles - All 6 versions
- ►jlr.org F Diraison, MA Ravier, SK Richards, RM … - The Journal of Lipid Research, 2008 - ASBMB Previous studies have reported both positive and negative effects of culture of
islets at high glucose concentrations on regulated insulin secretion. Here, we
have reexamined this question in mouse islets and determined the role of ... Cited by 4 - Related articles - All 5 versions
GA Rutter, MK Loder, MA Ravier - Biochemical Society Transactions, 2006 - biochemsoctrans.cn Abstract Minute-to-minute control of the release of insulin by pancreatic
β-cells in response to glucose or other stimuli requires the precise delivery
of large dense-core vesicles to the plasma membrane and regulated ... Cited by 3 - Related articles - View as HTML - BL Direct - All 7 versions
A Abderrahmani, V Plaisance, P Lovis, R … - Biochemical Society Transactions, 2006 - biochemsoctrans.org The last decade has witnessed spectacular progress in the identification of the
protein apparatus required for exocytosis of neurotransmitters, peptide hormones
and other bioactive products. In striking contrast, our knowledge of the ... Cited by 3 - Related articles - Cached - BL Direct - All 4 versions
T Tsuboi - Medical Molecular Morphology, 2008 - Springer Abstract Almost every cell in our organism releases pro- teins and other
biological substances using a fundamental cellular process known as constitutive
exocytosis. In con- trast, in exocrine and endocrine glands, the cells are ... Cited by 2 - Related articles - All 3 versions
