- ►hopkinsmedicine.org [PDF] SE Kahn, SM Haffner, MA Heise, WH Herman, … - New England Journal …, 2006 - content.nejm.org From the Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle
(SEK); University of Texas Health Science Center at San An tonio, San Antonio (SMH); GlaxoSmith
Kline, King of Prussia, PA (MAH, BGK, MCO), and Harlow, Essex, United King dom (NPJ); ... Cited by 781 - Related articles - BL Direct - All 30 versions
SE Kahn, RL Hull, KM Utzschneider - NATURE-LONDON-, 2006 - tesumassd.org The increased prevalence of obesity has focused attention on a world- wide problem that is not
one of famine or infection, but one of surplus. In the United States, only about a third of adults
are considered to be of 'normal' weight1, and similar trends are being observed ... Cited by 294 - Related articles - View as HTML - BL Direct - All 9 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
TA Buchanan, AH Xiang, RK Peters, SL Kjos, K … - Diabetes, 2000 - Am Diabetes Assoc The purpose of this study was to examine the response of pancreatic -cells to changes in insulin
sensitivity in women at high risk for type 2 diabetes. Oral glucose tol- erance tests (OGTTs) and
frequently sampled intra- venous glucose tolerance tests (FSIGTs) were con- ducted on ... Cited by 68 - Related articles - BL Direct - All 10 versions
J Munoz, KH Lok, BA Gower, JR Fernandez, GR Hunter … - Diabetes, 2006 - Am Diabetes Assoc Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been
linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide
polymorphisms (SNPs) rs12255372 and rs7903146. To investigate mechanisms by which ... Cited by 53 - Related articles - BL Direct - All 5 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
- ►diabetesjournals.org TA Buchanan - Diabetes, 2007 - Am Diabetes Assoc In the past 6 years, several randomized controlled trials have been conducted to test the impact
of behavioral and pharmacological interventions on rates of development of type 2 diabetes
in high-risk groups (1–7). The studies have demonstrated that it is possible to reduce the ... Cited by 23 - Related articles - BL Direct - All 4 versions
XQ Deng, LL Chen, NX Li - Liver International, 2007 - interscience.wiley.com Methods: Thirty-one male Wistar rats were divided at random into four groups. The rats in the
normal control group NC (n=7) and in the NAFLD model group HF (n=9) were fed ad libitum
with normal chow and high-fat diet, respectively, for 3 months, the rats in the calorie ... Cited by 21 - Related articles - BL Direct - All 3 versions
M Cnop, J Vidal, RL Hull, KM Utzschneider, DB … - Diabetes Care, 2007 - Am Diabetes Assoc RESULTS—Subjects gained weight, and their waist circumference increased (P < 0.05). Insulin
sensitivity, the acute insulin response to glucose, and glucose effectiveness did not change
significantly. However, when we accounted for the modulating effect of insulin sensitivity ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►cjb.net E Planel, Y Tatebayashi, T Miyasaka, L Liu, L … - Journal of …, 2007 - neuro.cjb.net Hyperphosphorylated tau is the major component of paired helical filaments in neurofibrillary
tangles found in Alzheimer's disease (AD) brains, and tau hyperphosphorylation is thought to
be a critical event in the pathogenesis of the disease. The large majority of AD cases is ... Cited by 23 - Related articles - All 4 versions
