DA Antonetti, AJ Barber, SK Bronson, WM Freeman, … - Diabetes, 2006 - Am Diabetes Assoc Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians.
Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 years
after its introduction. The ... Cited by 73 - Related articles - BL Direct - All 9 versions
TE Fox, X Han, S Kelly, AH Merrill, RE Martin, RE … - Diabetes, 2006 - Am Diabetes Assoc Dysregulated sphingolipid metabolism causes neuronal cell death and is associated with insulin
resistance and diseases. Thus, we hypothesized that diabetes-induced changes in retinal sphingolipid
metabolism may contribute to ... Cited by 12 - Related articles - BL Direct - All 6 versions
A Rajala, RE Anderson, JX Ma, J Lem, MR Al- … - Journal of Biological …, 2007 - ASBMB We have shown previously that phosphoinositide 3-kinase in the retina is activated in vivo through
light-induced tyrosine phosphorylation of the insulin receptor (IR). The light effect is localized
to photoreceptor neurons and is ... Cited by 7 - Related articles - All 5 versions
- ►jbc.org A Rajala, M Tanito, YZ Le, CR Kahn, RVS Rajala - Journal of Biological …, 2008 - ASBMB Insulin receptor (IR) signaling provides a trophic signal for transformed retinal neurons in
culture, but the role of IR activity in vivo is unknown. We previously reported that light causes
increased tyrosine phosphorylation ... Cited by 7 - Related articles - All 4 versions
T Tejada, P Catanuto, A Ijaz, JV Santos, X Xia, P … - Kidney International, 2008 - nature.com Loss of podocytes by apoptosis characterizes the early stages of diabetic nephropathy. To examine
its mechanism we studied glomeruli and podocytes isolated from db/db mice with early diabetic
nephropathy and albuminuria. ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►iovs.org T Kobayashi, DG Puro - Investigative ophthalmology & visual science, 2007 - ARVO RESULTS. Ischemia significantly increased apoptotic cell death in pericyte-containing microvessels
of the normal rat retina. In a dose-dependent (IC 50 = 600 pM) manner, physiological concentrations
of insulin markedly decreased ... Cited by 6 - Related articles - BL Direct - All 3 versions
MT Malecki, K Cyganek, B Mirkiewicz-Sieradzka, … - Diabetes Research and …, 2008 - Elsevier We examined 238 T2DM subjects without DR (NDR) and 121 with DR (mean diabetes duration: 9.1 ± 6.8
and 15.1 ± 7.7, respectively). The subjects were genotyped for four markers: Pro12Ala of PPARγ,
SNP43 of calpain 10, rs3787345 and ... Cited by 5 - Related articles - All 12 versions
- ►iovs.org SK Biswas, Y Zhao, A Nagalingam, TW Gardner, L … - … Ophthalmology & Visual …, 2008 - ARVO METHODS. Normal rat retinas and RGC-5 cells were used for (1) immunohistochemical and immunoblot
studies to detect PDGF receptor (PDGFR) subtypes and (2) immunoprecipitation, immunoblot, and in
vitro lipid kinase assays to ... Cited by 4 - Related articles - All 3 versions
- ►nih.gov RVS Rajala, B Wiskur, M Tanito, M Callegan, A … - … ophthalmology & visual …, 2009 - ARVO RESULTS. Immunohistochemical analysis of PTP1B shows that it is predominantly expressed in
nonphotoreceptor layers of the retina, though it is clearly expressed in the inner segments of the
rod photoreceptors. The IR is ... Cited by 4 - Related articles - All 4 versions
K Sugimoto, IB Rashid, M Shoji, T Suda, M Yasujima - Journal of Pain, 2008 - Elsevier The objective of the present study was to evaluate the time course of changes in peripheral nerve
insulin receptor (IR) signaling and compare observed findings with behavioral responses to noxious
mechanical and thermal stimuli in ... Cited by 3 - Related articles - All 27 versions
