- ►ahajournals.org MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that
is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused
by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose ... Cited by 164 - Related articles - All 7 versions
B Viollet, M Foretz, B Guigas, S Horman, R … - The Journal of …, 2006 - Physiological Soc It is now becoming evident that the liver has an important role in the control of whole body metabolism
of energy nutrients. In this review, we focus on recent findings showing that AMP-activated protein
kinase (AMPK) plays a major role in the control of hepatic metabolism. AMPK integrates ... Cited by 80 - Related articles - BL Direct - All 9 versions
- ►nih.gov [PDF] Y Shu, SA Sheardown, C Brown, RP Owen, … - Journal of Clinical …, 2007 - Am Soc Clin Investig Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic
cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the
therapeutic effects of the drug, which involve activation of AMP-activated protein kinase ( ... Cited by 80 - Related articles - BL Direct - All 9 versions
D Meley, C Bauvy, JHPM Houben-Weerts, PF … - Journal of Biological …, 2006 - ASBMB Interruption of mTOR-dependent signaling by rapamycin is known to stimulate autophagy, both
in mammalian cells and in yeast. Because activation of AMPK also inhibits mTOR-dependent
signaling one would expect stimulation of autophagy by AMPK activation. According to ... Cited by 58 - Related articles - All 7 versions
- ►jbc.org O Goransson, A McBride, SA Hawley, FA Ross, N … - Journal of Biological …, 2007 - ASBMB We have studied the mechanism of A-769662, a new activator of AMP-activated protein kinase
(AMPK). Unlike other pharmacological activators, it directly activates native rat AMPK by mimicking
both effects of AMP, ie allosteric activation and inhibition of dephosphorylation. We found ... Cited by 32 - Related articles - All 7 versions
- ►aspetjournals.org F Rencurel, M Foretz, MR Kaufmann, D Stroka, R … - Molecular pharmacology, 2006 - ASPET Our previous studies have suggested a role for AMP-activated protein kinase (AMPK) in the induction
of CYP2B6 by phenobarbital (PB) in hepatoma-derived cells (Rencurel et al., 2005 Go ). In this
study, we showed in primary human hepatocytes that: 1) 5'-phosphoribosyl-5- ... Cited by 29 - Related articles - All 6 versions
IB Sahra, K Laurent, A Loubat, S Giorgetti-Peraldi, P … - Oncogene, 2008 - nature.com Metformin is a widely used antidiabetic agent, which regulates glucose homeostasis through
inhibition of liver glucose production and an increase in muscle glucose uptake. Recent studies
suggest that metformin may reduce the risk of cancer, but its mode of action in cancer ... Cited by 25 - Related articles - BL Direct - All 4 versions
RL Jacobs, S Lingrell, JRB Dyck, DE Vance - Journal of Biological Chemistry, 2007 - ASBMB 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr), a commonly used indirect activator
of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly
isolated hepatocytes. In all nucleated mammalian cells, PC is synthesized from choline ... Cited by 21 - Related articles - All 5 versions
B Guigas, N Taleux, M Foretz, D Detaille, F … - The Biochemical …, 2007 - pubmedcentral.nih.gov AICA riboside (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) has been extensively
used in cells to activate the AMPK (AMP-activated protein kinase), a metabolic sensor involved
in cell energy homoeostasis. In the present study, we investigated the effects of AICA ... Cited by 20 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JM Ye, N Dzamko, AJ Hoy, MA Iglesias, B Kemp, E … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) has been implicated in the insulin-sensitizing actions of
thiazolidinediones (TZDs), but it is not known whether TZD treatment can enhance tissue glucose
uptake in response to AMPK activation. The present study investigated the influence of ... Cited by 19 - Related articles - BL Direct - All 5 versions
