X Liu, F Luo, K Pan, W Wu, H Chen - BMC Cell Biology, 2007 - biomedcentral.com Connective tissue growth factor (CTGF) is a potent profibrotic factor, which is implicated in fibroblast
proliferation, angiogenesis and extracellular matrix (ECM) synthesis. It is a downstream mediator
of some of the effects of transforming growth factor β (TGFβ) and is potentially induced by ... Cited by 22 - Related articles - Cached - All 11 versions
TA Gardiner, DB Archer, TM Curtis, AW Stitt - Microcirculation, 2007 - informahealthcare.com Diabetic retinopathy (DR) is the most widespread complication of diabetes mellitus and a major
cause of blindness in the working population of developed countries. The clinicopathology of
the diabetic retina has been extensively studied, although the relative contribution of the ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►jbc.org KV Ramana, AA Fadl, R Tammali, A Reddy, AK … - Journal of Biological …, 2006 - ASBMB Abnormal production of inflammatory cytokines and chemokines is a key feature of bacterial
endotoxin, lipopolysaccharide (LPS)-induced inflammation, and cytotoxicity; however, the mechanisms
regulating production of inflammatory markers remain unclear. Herein, we show that ... Cited by 18 - Related articles - All 7 versions
- ►nih.gov KV Ramana, SK Srivastava - Cytokine, 2006 - Elsevier Aldose reductase (AR; AKR1B1) a member of aldo-keto reductase super family, that we had
shown earlier mediates cytotoxic signals induced by high glucose, cytokines and growth
factors, also mediates the inflammatory signals induced by Gram-negative bacterial ... Cited by 9 - Related articles - All 5 versions
- ►iovs.org A Pladzyk, A Reddy, U Yadav, R Tammali, KV … - … ophthalmology & visual …, 2006 - ARVO METHODS. Growth-arrested HLECs were cultured without or with AR inhibitors or transfected
with an AR small interfering (si)RNA. Subsequently, the cells were stimulated with LPS (1-10
µg/mL) for 24 hours. The cell viability was assessed by cell counts and MTT assay, and ... Cited by 10 - Related articles - BL Direct - All 3 versions
- ►nih.gov KV Ramana, ABM Reddy, R Tammali, SK … - Free Radical Biology and …, 2007 - Elsevier Aldose reductase (AR) is a ubiquitously expressed protein with pleiotrophic roles as an efficient
catalyst for the reduction of toxic lipid aldehydes and mediator of hyperglycemia, cytokine, and
growth factor-induced redox-sensitive signals that cause secondary diabetic ... Cited by 7 - Related articles - All 7 versions
Z Kabututu, M Manin, JC Pointud, T … - Journal of …, 2009 - Jpn Biochemical Soc Here, we show that three enzymes belonging to the 1B group of the aldo–keto reductase
(AKR) superfamily, ie, human placental aldose reductase (AKR1B1), mouse kidney aldose reductase
(AKR1B3) and mouse vas deferens protein (AKR1B7), catalyse the reduction of ... Cited by 4 - Related articles - All 6 versions
A Reddy, KV Ramana, S Srivastava, A Bhatnagar, SK … - Endocrinology, 2009 - Endocrine Soc Chronic low-grade inflammation has emerged as a key contributor to the cardiovascular complications
of diabetes, however, the mechanisms by which diabetes increases inflammation remain poorly
understood. Here, we report that exposure to high glucose (HG) stimulates ectodomain ... Cited by 3 - Related articles - All 3 versions
R Tammali, A Reddy, KV Ramana, JM Petrash, SK … - Carcinogenesis, 2009 - Oxford Univ Press Aldose reductase (AR; EC 1.1.1.21 [EC] ), an nicotinamide adenine dinucleotide
phosphate-dependent aldo–keto reductase, has been shown to be involved in oxidative stress
signaling initiated by inflammatory cytokines, chemokines and growth factors. Recently, ... Related articles - All 3 versions
KY Hung, SY Liu, SH Kao, JW Huang, CK … - American Journal of …, 2008 - content.karger.com Background/Aims: High-glucose (HG)-induced mesangial apoptosis and fibrogenesis possibly
involves reactive oxygen species (ROS) formation and activated mitochondrial stress. We investigated
the therapeutic effect of the antioxidant N-acetylcysteine (NAC) on cellular apoptosis and ... Cited by 1 - Related articles - All 4 versions
