- ►jhsph.edu [PDF] CM Larsen, M Faulenbach, A Vaag, A Volund, … - The New England journal of medicine, 2007 - nejm.highwire.org Methods In this double-blind, parallel-group trial involving 70 patients with
type 2 diabetes, we randomly assigned 34 patients to receive 100 mg of anakinra
(a recombinant human interleukin-1–receptor antagonist) subcutaneously ... Cited by 138 - Related articles - BL Direct - All 12 versions
- ►nih.gov AP Coll, IS Farooqi, S O'Rahilly - Cell, 2007 - Elsevier Despite marked day-to-day fluctuations in food intake and physical activity,
most healthy adult mammals maintain a steady body weight over many years. This
indicates that cumulative energy intake is normally matched with great ... Cited by 86 - Related articles - All 14 versions
- ►shouxi.net MC García, I Wernstedt, A Berndtsson, M Enge … - Diabetes, 2006 - Am Diabetes Assoc Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its
biological activities through the IL-1 type I receptor (IL-1RI). The body
weights of IL-1RI −/− mice of both sexes started to deviate from those ... Cited by 36 - Related articles - BL Direct - All 7 versions
- ►pnas.org EP Zorrilla, M Sanchez-Alavez, S Sugama, M … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in
obesity. Here, we show that administration of IL-18 suppresses appetite, feed
efficiency, and weight regain in food-deprived male and female C57BL/6J ... Cited by 16 - Related articles - BL Direct - All 8 versions
EC Eringa, W Bakker, YM Smulders, EH … - Microcirculation, 2007 - informahealthcare.com Obesity is associated with insulin resistance, hypertension and cardiovascular
disease, but the mechanisms underlying these associations are incompletely
understood. Microvascular dysfunction may play an important role in the ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►endojournals.org L Strandberg, M Lorentzon, A Hellqvist, S … - Journal of Clinical Endocrinology & Metabolism, 2006 - Endocrine Soc Context: There is growing evidence for interactions between the regulation of
body fat and the immune system. Studies of knockout mice indicate that IL-1 has
an antiobesity effect. ... Objective: The objective of the study was to ... Cited by 12 - Related articles - BL Direct - All 9 versions
- ►gnmhealthcare.com [PDF] KW Carter, J Hung, BL Powell, S Wiltshire, … - Human Genetics, 2008 - Springer Abstract The objective of this study was to determine whether single nucleotide
polymorphisms (SNPs) in the Interleukin-1 (IL-1) gene family are associated with
central obesity and metabolic syndrome in a coronary heart disease ... Cited by 5 - Related articles - All 4 versions
O Osborn, SE Brownell, M Sanchez-Alavez, D … - Cytokine, 2008 - Elsevier The proinflammatory cytokine Interleukin 1 beta (IL-1β) is elevated in obese
individuals and rodents and it is implicated in impaired insulin secretion,
decreased cell proliferation and apoptosis of pancreatic beta cells. In ... Cited by 5 - Related articles - All 3 versions
L Strandberg, D Mellström, Ö Ljunggren, E … - Obesity, 2008 - nature.com There is growing evidence that immune functions are linked to the regulation of
body fat. Our studies of knockout mice indicate that both endogenous interleukin
(IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated ... Cited by 6 - Related articles - All 2 versions
S Rafiq, D Melzer, MN Weedon, H Lango, R … - Diabetologia, 2008 - Springer Page 1. ARTICLE Gene variants influencing measures of inflammation or
predisposing to autoimmune and inflammatory diseases are not ... Cited by 4 - Related articles - All 4 versions
