S Musatov, W Chen, DW Pfaff, CV Mobbs … - Proceedings of the …, 2007 - National Acad Sciences Estrogen receptor α (ERα) plays a pivotal role in the regulation of food intake and energy expenditure
by estrogens. Although it is well documented that a disruption of ERα signaling in ERα knockout
(ERKO) mice leads to an obese phenotype, the sites of estrogen action and mechanisms ... Cited by 61 - Related articles - BL Direct - All 7 versions
- ►endojournals.org S Yakar, NP Nunez, P Pennisi, P Brodt, H Sun, L … - Endocrinology, 2006 - Endocrine Soc Obesity increases the risk of many cancers in both males and females. This study describes a
link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer
in male and female mice. The goal of this study was to evaluate the relationship between ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►nih.gov M Björnholm, H Münzberg, RL Leshan, EC … - Journal of Clinical …, 2007 - Am Soc Clin Investig The adipose-derived hormone, leptin, acts via its receptor (LRb) to convey the status of body
energy stores to the brain, decreasing feeding and potentiating neuroendocrine energy
expenditure. The failure of high levels of leptin in most obese individuals to promote ... Cited by 26 - Related articles - BL Direct - All 9 versions
DJ Clegg, LM Brown, JM Zigman, CJ Kemp, AD Strader … - Diabetes, 2007 - Am Diabetes Assoc Ghrelin, the only known orexigenic gut hormone, is secreted mainly from the stomach, increases
with fasting and before meal initiation in humans and rats, and increases food intake after central
or peripheral administration. To investigate sex differences in the action of ghrelin, we ... Cited by 26 - Related articles - BL Direct - All 14 versions
- ►nih.gov MJ Kelly, OK Rønnekleiv - Molecular and cellular endocrinology, 2008 - Elsevier It is well known that many of the actions of 17β-estradiol (E2) in the central nervous system are
mediated via intracellular receptor/transcription factors that interact with steroid response elements
on target genes. However, there is compelling evidence for membrane steroid receptors ... Cited by 25 - Related articles - All 4 versions
- ►physiology.org Q Gao, TL Horvath - American Journal of Physiology- …, 2008 - Am Physiological Soc Obesity, characterized by enhanced food intake (hyperphagia) and reduced energy expenditure
that results in the accumulation of body fat, is a major risk factor for various diseases, including
diabetes, cardiovascular disease, and cancer. In the United States, more than half of ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►endojournals.org MH Vickers, PD Gluckman, AH Coveny, PL Hofman, … - Endocrinology, 2008 - Endocrine Soc An adverse prenatal environment may induce long-term metabolic consequences, in particular
obesity, hyperleptinemia, insulin resistance, and type 2 diabetes. Although the mechanisms are
unclear, this "programming" has generally been considered an irreversible change in ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►endojournals.org AW Xu, L Ste-Marie, CB Kaelin, GS Barsh - Endocrinology, 2007 - Endocrine Soc Leptin is an adipocyte-derived hormone that signals body energy status to the brain by acting
on multiple neuronal subgroups in the hypothalamus, including those that express proopiomelanocortin
(Pomc) and agouti-related protein (Agrp). Signal transducer and activator of transcription ... Cited by 18 - Related articles - BL Direct - All 3 versions
M Hallschmid, C Benedict, B Schultes, J Born, W … - International Journal of …, 2007 - nature.com Insulin acts in the brain to reduce food intake and body weight and is considered a major adiposity
signal in energy homeostasis. In normal-weight men, intranasal insulin administration reduces
body fat and improves declarative memory. The present experiments aimed to generalize ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►endojournals.org C Benedict, W Kern, B Schultes, J Born, M … - Journal of Clinical …, 2008 - Endocrine Soc Context: Brain insulin is critically involved in the regulation of body weight and memory
processing. Long-term administration of intranasal insulin reduces body weight in men, but not
in women, while improving hippocampus-dependent memory processing in both genders. Cited by 13 - Related articles - BL Direct - All 4 versions
