- ►rh.dk [PDF] LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier This review focuses on the mechanisms regulating the synthesis, secretion,
biological actions, and therapeutic relevance of the incretin peptides
glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like ... Cited by 173 - Related articles - All 25 versions
- ►nih.gov DJ Drucker - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The gastrointestinal tract has a crucial role in the control of energy
homeostasis through its role in the digestion, absorption, and assimilation of
ingested nutrients. Furthermore, signals from the gastrointestinal tract ... Cited by 85 - Related articles - BL Direct - All 11 versions
LC Alonso, T Yokoe, P Zhang, DK Scott, SK … - Diabetes, 2007 - Am Diabetes Assoc Developing new techniques to induce β-cells to replicate is a major goal in
diabetes research. Endogenous β-cells replicate in response to metabolic
changes, such as obesity and pregnancy, which increase insulin requirement. ... Cited by 28 - Related articles - BL Direct - All 5 versions
DN Gross, M Wan, MJ Birnbaum - Current Diabetes Reports, 2009 - Springer Forkhead box O (FOXO) transcription factors play an important role in modulating
metabolic func- tions. FOXO is regulated by several modifications, but one of
the most critical is phosphorylation and nuclear exclusion by Akt. Given ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org DA Glauser, W Schlegel - Journal of Endocrinology, 2007 - Soc Endocrinology FOXO transcription factors critically control fundamental cellular processes,
including metabolism, cell differentiation, cell cycle arrest, DNA repair, and
other reactions to cellular stress. FOXO factors sense the balance between ... Cited by 20 - Related articles - BL Direct - All 2 versions
- ►jbc.org J Buteau, A Shlien, S Foisy, D Accili - Journal of Biological Chemistry, 2007 - ASBMB Diabetes is associated with decreased pancreatic -cell function and mass. It is
unclear whether diabetes treatment should aim at restoring -cell
performance/mass or at inducing " -cell rest" to prevent further ... Cited by 20 - Related articles - All 6 versions
- ►nih.gov RD Wideman, ILY Yu, TD Webber, CB Verchere … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences Glucagon-like peptide 1 (GLP-1) is a hormone that has received significant
attention as a therapy for diabetes because of its ability to stimulate insulin
biosynthesis and release and to promote growth and survival of ... Cited by 21 - Related articles - BL Direct - All 10 versions
MMJ Combettes - Current opinion in pharmacology, 2006 - Elsevier The first antidiabetic treatment (exenatide; Byetta) based on the incretin
hormone glucagon-like peptide-1 (GLP-1) was approved in 2005 as an adjunctive
therapy in diabetic patients in whom sulfonylurea, metformin or both had ... Cited by 15 - Related articles - All 3 versions
- ►endojournals.org M Salehi, BA Aulinger, DA D'Alessio - Endocrine Reviews, 2008 - Endocrine Soc THE LAST TWO DECADES have seen a major shift in the consensus on the
pathogenesis of type 2 diabetes mellitus (T2DM). Although it is clear that
resistance of peripheral tissues to insulin is an abnormality common to ... Cited by 13 - Related articles - BL Direct - All 4 versions
Z Liu, K Tanabe, E Bernal-Mizrachi, MA … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Glycogen synthase kinase-3 (GSK3) has been implicated
in the pathophysiology of several prevalent diseases, including diabetes.
However, despite recent progress in our understanding of the role of GSK3 ... Cited by 12 - Related articles - BL Direct - All 3 versions
