KC Kregel, HJ Zhang - American Journal of Physiology- …, 2007 - Am Physiological Soc Aging is an inherently complex process that is manifested within an organism at genetic,
molecular, cellular, organ, and system levels. Although the fundamental mechanisms are still
poorly understood, a growing body of evidence points toward reactive oxygen species ... Cited by 93 - Related articles - BL Direct - All 6 versions
- ►clinchem.org S de Ferranti, D Mozaffarian - Clinical chemistry, 2008 - Am Assoc Clin Chem Content: In this report we review adipocyte metabolism and function in the context of energy
imbalance and postprandial nutrient excess, including adipocyte hypertrophy and
hyperplasia, adipocyte dysfunction, and other systemic consequences. We also discuss ... Cited by 50 - Related articles - BL Direct - All 5 versions
A Matsuzawa, H Ichijo - BBA-General Subjects, 2008 - Elsevier The intracellular redox state is a key determinant of cell fate, such as cell survival,
proliferation, differentiation, and apoptosis. Redox imbalance is closely linked to a variety of human
diseases, so that the intracellular redox condition should be tightly regulated. The redox ... Cited by 39 - Related articles - All 2 versions
- ►aacrjournals.org PL Kuo, CY Chen, YL Hsu - Cancer Research, 2007 - AACR Breast cancer is one of the most common malignancies in women and is the leading cause of
death worldwide for women between the ages of 40 and 55 (1). This pathology is currently controlled
by surgery and radiotherapy and is frequently supported by adjuvant chemo- or ... Cited by 22 - Related articles - BL Direct - All 2 versions
M Vidali, MF Tripodi, A Ivaldi, R Zampino, G Occhino, L … - Journal of Hepatology, 2008 - Elsevier Oxidative stress was present in 61% of the patients, irrespective of age, gender, viral load,
BMI, aminotransferase level, histology activity index (HAI) and HCV genotype. Insulin resistance
and steatosis were evident in 80% and 70% of the patients, respectively. In the patients ... Cited by 14 - Related articles - All 7 versions
- ►nih.gov SL Milton, HM Prentice - Comparative Biochemistry and Physiology, Part A, 2007 - Elsevier The freshwater turtle Trachemys scripta is among the most anoxia-tolerant of vertebrates, a true
facultative anaerobe able to survive without oxygen for days at room temperature to weeks or
months during winter hibernation. Our good friend and colleague Peter Lutz devoted ... Cited by 11 - Related articles - All 6 versions
- ►oxfordjournals.org PLK Lim, J Liu, ML Go, UA Boelsterli - Toxicological Sciences, 2008 - Soc Toxicology Although the mechanisms and susceptibility factors of troglitazone-associated idiosyncratic liver
injury have not been elucidated, experimental evidence has identified oxidant stress and mitochondrial
injury as a potential hazard in vitro. In search of upstream mediators of toxicity, we ... Cited by 11 - Related articles - BL Direct - All 5 versions
T Nishikawa, D Kukidome, K Sonoda, K Fujisawa, T … - Diabetes Research and …, 2007 - Elsevier Tumor necrosis factor-alpha (TNF-α) inhibits insulin action, in part, by activating c-jun NH 2 -terminal
kinases (JNK). However, the precise mechanisms by which TNF-α activates JNK are
unknown. Recently, we confirmed that hyperglycemia increased mitochondrial reactive ... Cited by 9 - Related articles - All 9 versions
- ►diabetesjournals.org N Kumashiro, Y Tamura, T Uchida, T Ogihara, Y … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—db/db mice had high ROS levels in liver. Overexpression of SOD1 in liver of db/db
mice reduced hepatic ROS and blood glucose level. These changes were accompanied by improvement
in insulin resistance and reduction of hepatic gene expression of phosphoenol-pyruvate ... Cited by 12 - Related articles - All 5 versions
- ►endojournals.org N Bashan, K Dorfman, T Tarnovscki, I Harman-Boehm, … - Endocrinology, 2007 - Endocrine Soc MAPKs and inhibitory- B kinase (IKK) were suggested to link various conditions thought to develop
in adipose tissue in obesity (oxidative, endoplasmic reticulum stress, inflammation) with insulin
resistance. Yet whether in obesity these kinases are affected in a fat-depot-differential ... Cited by 10 - Related articles - BL Direct - All 3 versions
