- ►jhsph.edu [PDF] CM Larsen, M Faulenbach, A Vaag, A … - The New England …, 2007 - nejm.highwire.org Methods In this double-blind, parallel-group trial involving 70 patients with type 2 diabetes, we
randomly assigned 34 patients to receive 100 mg of anakinra (a recombinant human
interleukin-1–receptor antagonist) subcutaneously once daily for 13 weeks and 36 ... Cited by 144 - Related articles - BL Direct - All 12 versions
D Chida, T Osaka, O Hashimoto, Y Iwakura - Diabetes, 2006 - Am Diabetes Assoc Proinflammatory cytokines including interleukin (IL)-1 and IL-6 exert pleiotropic effects on the
neuro-immuno-endocrine system. Previously, we showed that IL-1 receptor antagonist–deficient
(IL-1Ra −/− ) mice show a lean phenotype due to an abnormal lipid metabolism. On the ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Manneras, S Cajander, A Holmang, Z Seleskovic, T … - Endocrinology, 2007 - Endocrine Soc Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated
with ovulatory dysfunction, hyperandrogenism, abdominal obesity, and insulin resistance.
However, its etiology is unclear, and its management is often unsatisfactory or requires a ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►simplifica.net [PDF] M López, S Tovar, MJ Vázquez, LM … - Proceedings of the …, 2007 - Cambridge Univ Press More than 70 years ago the glucostatic, lipostatic and aminostatic hypotheses proposed that
the central nervous system sensed circulating levels of different metabolites, changing feeding
behaviour in response to the levels of those molecules. In the last 20 years the rapid ... Cited by 19 - Related articles - BL Direct - All 10 versions
- ►endojournals.org JM Scarlett, EE Jobst, PJ Enriori, DD Bowe, AK Batra, … - Endocrinology, 2007 - Endocrine Soc Anorexia and involuntary weight loss are common and debilitating complications of a number
of chronic diseases and inflammatory states. Proinflammatory cytokines, including IL-1ß, are
hypothesized to mediate these responses through direct actions on the central nervous ... Cited by 19 - Related articles - BL Direct - All 3 versions
- ►nutrition.org J Shen, DK Arnett, JM Peacock, LD Parnell, A … - Journal of …, 2007 - Am Soc Nutrition Chronic inflammation has been identified as an important component of the metabolic syndrome
(MetS). Therefore, environmental and genetic factors contributing to the variation of inflammatory
responses could affect individuals' susceptibility to MetS. We investigated the association ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►pnas.org EP Zorrilla, M Sanchez-Alavez, S … - Proceedings of the …, 2007 - National Acad Sciences Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity. Here, we show
that administration of IL-18 suppresses appetite, feed efficiency, and weight regain in food-deprived
male and female C57BL/6J mice. Intraperitoneal vs. intracerebroventricular routes of ... Cited by 17 - Related articles - BL Direct - All 8 versions
- ►endojournals.org L Strandberg, M Lorentzon, A Hellqvist, S … - Journal of Clinical …, 2006 - Endocrine Soc Context: There is growing evidence for interactions between the regulation of body fat and the
immune system. Studies of knockout mice indicate that IL-1 has an antiobesity effect. ...
Objective: The objective of the study was to investigate our hypothesis that common ... Cited by 12 - Related articles - BL Direct - All 9 versions
E Pinteaux, W Inoue, L Schmidt, F Molina-Holgado … - J …, 2007 - interscience.wiley.com Leptin regulates energy balance by suppressing appetite and increasing energy expenditure
through actions in the hypothalamus. Recently we demonstrated that the effects of leptin are,
at least in part, mediated by the release of interleukin (IL)-1β in the brain. Microglia ... Cited by 9 - Related articles - BL Direct - All 5 versions
