- ►oxfordjournals.org H Freeman, RD Cox - Human molecular genetics, 2006 - Oxford Univ Press Diabetes is one of the most challenging health problems of the 21st century with an alarming
increase in the prevalence of type-2 diabetes mellitus (T2DM) and associated conditions such
as hypertension, dyslipidemias and obesity. T2DM is a complex genetic disease ... Cited by 48 - Related articles - BL Direct - All 8 versions
DM Lehman, DK Richardson, CP Jenkinson, KJ Hunt, … - Diabetes, 2007 - Am Diabetes Assoc Common and rare variants of the hepatocyte nuclear factor 4α (HNF4A) gene have been associated
with type 2 diabetes and related traits in several populations suggesting the involvement of this
transcription factor in diabetes pathogenesis. Single nucleotide polymorphisms (SNPs) ... Cited by 12 - Related articles - BL Direct - All 5 versions
GVZ Dedoussis, AC Kaliora, DB … - The Review of Diabetic …, 2007 - pubmedcentral.nih.gov Diabetes mellitus is widely recognized as one of the leading causes of death and disability. While
insulin insensitivity is an early phenomenon partly related to obesity, pancreatic β-cell function
declines gradually over time even before the onset of clinical hyperglycemia. Several ... Cited by 8 - Related articles - All 4 versions
- ►diabetesjournals.org I Barroso, J Luan, E Wheeler, P Whittaker, J Wasson, E … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A
were originally shown to be associated with predisposition for type 2 diabetes in Finnish,
Ashkenazi, and, more recently, Scandinavian populations, but they generated conflicting ... Cited by 7 - Related articles - All 8 versions
L Love-Gregory, MA Permutt - Current Opinion in Clinical Nutrition & …, 2007 - journals.lww.com Purpose of review: Variants in the hepatocyte nuclear factor 4α (HNF4A) gene play a role in the
development of diabetes mellitus. Although genetic variation in and around HNF4A regulatory
regions has received considerable attention, the significance of these variants in the ... Cited by 6 - Related articles - BL Direct - All 5 versions
F Takeuchi, K Yanai, H Inomata, N Kuzuya, H Kajio, … - … and Biophysical Research …, 2007 - Elsevier Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad
region on chromosome 20q, where the hepatocyte nuclear factor-4α (HNF4A) has been noted
as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the ... Cited by 4 - Related articles - All 6 versions
AK Gerdin, VV Surve, M Jönsson, M Bjursell, M … - … and Biophysical Research …, 2006 - Elsevier Using the mouse as a model organism in pharmaceutical research presents unique advantages
as its physiology in many ways resembles the human physiology, it also has a relatively short
generation time, low breeding and maintenance costs, and is available in a wide variety ... Cited by 6 - Related articles - All 6 versions
LW Harries - Expert Review of Endocrinology and Metabolism, 2006 - ingentaconnect.com Variation in mRNA processing has the capacity to exert fine control over gene expression in
most cell types. The hepatic nuclear factor genes, like approximately 74% of the genome, produce
multiple transcripts. Hepatic nuclear factor isoforms exhibit both spatial and temporal ... Cited by 3 - Related articles - All 3 versions
MN Weedon, TM Frayling - Current Diabetes Reports, 2007 - Springer Introduction Maturity-onset diabetes of the young (MODY) is a type of non–insulin-dependent
diabetes mellitus caused by rare autosomal-dominant mutations, accounting for 1% to 2% of
diabetes cases. Patients with MODY usually pres- ent before the age of 25 and often have ... Cited by 2 - Related articles - BL Direct - All 2 versions
JD Walston, KD Silver - Geriatric diabetes, 2007 - books.google.com 2 The Genetics of Diabetes and Its Complications in Older Adults Jeremy D. Walston Department
of Medicine, Johns Hopkins University, Baltimore, MaryIand, USA Kristi D. Silver Division of
Endocrinology, Department of Medicine, Diabetes, and Nutrition, University of Maryland, ... Cited by 1 - Related articles
