KT Chambers, JA Unverferth, SM Weber, RC … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—UPR activation correlates with β-cell death in interleukin
(IL)-1–treated rat islets. NO mediates both cytokine-induced UPR activation
and β-cell death as NO synthase inhibitors attenuate each of these IL-1– ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►endojournals.org PT Fueger, JC Schisler, D Lu, DA Babu, RG … - Molecular Endocrinology, 2008 - Endocrine Soc Both major forms of diabetes involve a decline in β-cell mass, mediated by
autoimmune destruction of insulin-producing cells in type 1 diabetes and by
increased rates of apoptosis secondary to metabolic stress in type 2 ... Cited by 9 - Related articles - BL Direct - All 5 versions
C Holohan, E Szegezdi, T Ritter, T O'Brien, A … - J Cell Mol Med, 2008 - interscience.wiley.com Pro-inflammatory cytokines are implicated as the main mediators of β-cell death
during type 1 diabetes but the exact mechanisms remain unknown. This study
examined the effects of interleukin-1β (IL-1β), interferon-γ (IFNγ) and ... Cited by 7 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org D Su, N Zhang, J He, S Qu, S Slusher, R … - Diabetes, 2007 - Am Diabetes Assoc Successful islet transplantation depends on the infusion of sufficiently large
quantities of islets, but only a small fraction of implanted islets become
engrafted. The underlying mechanisms remain elusive. To probe the mechanism ... Cited by 5 - Related articles - BL Direct - All 4 versions
DD Paula, MVLB Bentley, RI Mahato - Journal of drug targeting, 2007 - informahealthcare.com Methods: Rat insulinoma INS-1E cells were transfected with chemically
synthesized siRNA after complex formation with Lipofectamine 2000. Cells were
then treated with a cocktail of inflammatory cytokines (IL-1β+ TNF-α+ ... Cited by 6 - Related articles - BL Direct - All 6 versions
- ►endojournals.org R Arumugam, E Horowitz, D Lu, JJ Collier, … - Endocrinology, 2008 - Endocrine Soc Carbohydrate metabolism in pregnancy reflects the balance between
counterregulatory hormones, which induce insulin resistance, and lactogenic
hormones, which stimulate β-cell proliferation and insulin production. ... Cited by 4 - Related articles - All 3 versions
SJ Burke, JJ Collier, DK Scott - The FASEB Journal, 2009 - FASEB Glucose-mediated activation of the L-type pyruvate kinase (L-PK) gene is
repressed by cAMP, making this an excellent model for studying the mechanism by
which these contrary signals regulate gene expression. Using the 832/13 rat ... Cited by 2 - Related articles - All 3 versions
- ►physiology.org KT Chambers, SM Weber, JA Corbett - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Peroxisome proliferator-activated receptor- (PPAR ) ligands have been shown to
possess anti-inflammatory properties that include the inhibition of
transcription factor activation and the expression of inflammatory genes. ... Cited by 2 - Related articles - BL Direct - All 4 versions
G Szabadkai, MR Duchen - Apoptosis - Springer Abstract Mitochondrial dysfunction plays a role in the pathogenesis of a wide
range of diseases that involve dis- ordered cellular fuel metabolism and
survival/death path- ways, including neurodegenerative diseases, cancer and ... Related articles - All 2 versions
