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Scholar Results 1 - 10 of about 21 citing Kwan: Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. (0.12 sec) 

Fatty acid signaling in the β-cell and insulin secretion

- diabetesjournals.org
CJ Nolan, MSR Madiraju, V Delghingaro- … - Diabetes, 2006 - Am Diabetes Assoc
Fatty acids (FAs) and other lipid molecules are important for many cellular
functions, including vesicle exocytosis. For the pancreatic β-cell, while the
presence of some FAs is essential for glucose-stimulated insulin secretion, ...
Cited by 54 - Related articles - BL Direct - All 5 versions

UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in …

- jneurosci.org
S Speese, M Petrie, K Schuske, M Ailion, K … - Journal of Neuroscience, 2007 - Soc Neuroscience
Previous studies indicated that CAPS (calcium-dependent activator protein for
secretion) functions as an essential component for the Ca 2+ -dependent
exocytosis of dense-core vesicles in neuroendocrine cells. However, recent ...
Cited by 25 - Related articles - All 7 versions

PKC-1 regulates secretion of neuropeptides


D Sieburth, JM Madison, JM Kaplan - Nature Neuroscience, 2006 - nature.com
The secretion of neurotransmitters and neuropeptides is mediated by distinct
organelles—synaptic vesicles (SVs) and dense-core vesicles (DCVs),
respectively. Relatively little is known about the factors that ...
Cited by 23 - Related articles - BL Direct - All 3 versions

Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated …

- shouxi.net
EP Kwan, L Xie, L Sheu, T Ohtsuka, HY … - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—To determine which exocytotic steps caused by Munc13-1 deficiency are
rescued by Epac2 and PKA, we used patch-clamp capacitance measurements, showing
that 1) cAMP restored the reduced readily releasable pool (RRP) and ...
Cited by 16 - Related articles - BL Direct - All 4 versions

SNAREing Voltage-Gated K+ and ATP-Sensitive K+ Channels: Tuning {beta}-Cell Excitability …

- endojournals.org
YM Leung, EP Kwan, B Ng, Y Kang, HY … - Endocrine reviews, 2007 - Endocrine Soc
The three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein
receptor) proteins, syntaxin, SNAP25 (synaptosome-associated protein of 25 kDa),
and synaptobrevin, constitute the minimal machinery for exocytosis in ...
Cited by 16 - Related articles - BL Direct - All 3 versions

Glycerolipid metabolism and signaling in health and disease

- endojournals.org
M Prentki, SR Madiraju - Endocrine reviews, 2008 - Endocrine Soc
GL/FFA cycle is referred to as a "futile" cycle because it involves continuous
formation and hydrolysis of GL with the release of heat, at the expense of ATP.
However, we present evidence underscoring the "vital" cellular signaling ...
Cited by 14 - Related articles - All 5 versions

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta- …

- fasebj.org
J Chen, ST Hui, FM Couto, IN Mungrue, DB … - The FASEB Journal, 2008 - FASEB
Pancreatic beta-cell loss through apoptosis represents a key factor in the
pathogenesis of diabetes; however, no effective approaches to block this process
and preserve endogenous beta-cell mass are currently available. To study ...
Cited by 11 - Related articles - All 5 versions

Doc2β Is a Novel Munc18c-interacting Partner and Positive Effector of Syntaxin 4-mediated …


B Ke, E Oh, DC Thurmond - Journal of Biological Chemistry, 2007 - ASBMB
The widely expressed Sec/Munc18 (SM) protein Munc18c is required for
SNARE-mediated insulin granule exocytosis from islet beta cells and GLUT4
vesicle exocytosis in skeletal muscle and adipocytes. Although Munc18c ...
Cited by 10 - Related articles - All 5 versions

The role of incretins in glucose homeostasis and diabetes treatment

- nih.gov
W Kim, JM Egan - Pharmacological reviews, 2008 - ASPET
Cited by 11 - Related articles - All 5 versions

Munc13-4 regulates granule secretion in human neutrophils

- jimmunol.org
C Pivot-Pajot, F Varoqueaux, G de Saint … - The Journal of Immunology, 2008 - Am Assoc Immnol
The neutrophil plays a central role in the innate host immune defense. Regulated
exocytosis of its granules and release of antimicrobial and cytotoxic substances
are key events to limit the spread of pathogens. However, the molecular ...
Cited by 7 - Related articles - BL Direct - All 2 versions


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