- ►nih.gov MC Arrieta, L Bistritz, JB Meddings - British Medical Journal, 2006 - gut.bmj.com From the lower oesophageal sphincter to the anus, the gastrointestinal tract has a single contiguous
layer of cells that separates the inside of the body from the external environment. Separation
is important as there are a wide variety of environmental agents in the lumen of the bowel ... Cited by 41 - Related articles - BL Direct - All 7 versions
- ►nih.gov KM Lammers, R Lu, J Brownley, B Lu, C Gerard, K … - Gastroenterology, 2008 - Elsevier Background & Aims: Celiac disease is an immune-mediated enteropathy triggered by
gliadin, a component of the grain protein gluten. Gliadin induces an MyD88-dependent zonulin
release that leads to increased intestinal permeability, a postulated early element in the ... Cited by 23 - Related articles - All 4 versions
C Nunez, A Marquez, J Varade, A Martinez, I … - Tissue …, 2006 - interscience.wiley.com Inconsistent results concerning the association of polymorphisms in the MYO9B gene with celiac
disease (CD) have been recently published. This gene encodes a myosin with a
guanosine-triphosphatase (GTPase)-activating protein domain for the Rho-family of small ... Cited by 21 - Related articles - All 4 versions
- ►direct-ms.org [PDF] E Bosi, L Molteni, MG Radaelli, L Folini, I Fermo, E … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Recent observations have shown subclin- ical intestinal abnormalities
in human type 1 diabetes. Whether these are related to the pathogenetic process or secondary
to the diabetes remains to be clarified. The aim of this study was to investigate this issue ... Cited by 16 - Related articles - BL Direct - All 5 versions
O Vaarala, MA Atkinson, J Neu - Diabetes, 2008 - Am Diabetes Assoc It is often stated that type 1 diabetes results from a complex interplay between varying degrees
of genetic susceptibility and environmental factors. While agreeing with this principal, our desire
is that this Perspectives article will highlight another complex interplay potentially ... Cited by 10 - Related articles - All 5 versions
- ►amjpathol.org A Fasano - American Journal of Pathology, 2008 - ASIP The anatomical and functional arrangement of the gastrointestinal tract suggests that this
organ, beside its digestive and absorptive functions, regulates the trafficking of macromolecules
between the environment and the host through a barrier mechanism. Under physiological ... Cited by 6 - Related articles - All 6 versions
JL Santiago, A Martínez, C Núñez, H de la Calle, M … - Human Immunology, 2008 - Elsevier MYO9B (myosin IXB) polymorphisms were associated with celiac disease and ulcerative colitis
susceptibility, presumably through alteration of the intestinal permeability. Recently this gene
was also associated with several diseases with an autoimmune component, such as ... Cited by 5 - Related articles - All 3 versions
S Ballotti, M de Martino - Journal of pediatric gastroenterology and …, 2007 - journals.lww.com Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by altered immune tolerance
to specific proteins leading to a selective destruction of insulin-producing β cells in genetically
predisposed individuals. T1D is likely to be triggered by environmental factors, including ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►nih.gov MC Arrieta, K Madsen, J Doyle, J Meddings - British Medical Journal, 2009 - gut.bmj.com Background: Defects in the small intestinal epithelial barrier have been associated with inflammatory
bowel disease but their role in the causation of disease is still a matter of debate. In some models
of disease increased permeability appears to be a very early event. The interleukin 10 ... Cited by 4 - Related articles - All 9 versions
O Vaarala - Current opinion in gastroenterology, 2008 - journals.lww.com Recent findings: Recent studies indicate that not only patients with manifest type 1 diabetes show
increased small intestinal permeability and high serum levels of zonulin, that is protein controlling
epithelial tight junctions, but prediabetic, normoglycemic individuals with β-cell ... Cited by 2 - Related articles - All 3 versions
