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Scholar Results 1 - 10 of about 39 citing Gable: Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes.... (0.12 sec) 

Uncoupling protein-3: clues in an ongoing mitochondrial mystery

- fasebj.org
V Bezaire, EL Seifert, ME Harper - The FASEB Journal, 2007 - FASEB
Uncoupling protein (UCP) 3 (UCP3) is a mitochondrial anion carrier protein with
highly selective expression in skeletal muscle. Despite a great deal of
interest, to date neither its molecular mechanism nor its biochemical and ...
Cited by 49 - Related articles - BL Direct - All 4 versions

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study

- diabetesjournals.org
M Vaxillaire, J Veslot, C Dina, C Proença, S … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS— The GCK (Glucokinase) −30A allele was associated with increased
type 2 diabetes risk at the end of the follow-up study (adjusted OR 1.34 [95% CI
1.07–1.69]) under an additive model, as supported in independent French ...
Cited by 34 - Related articles - BL Direct - All 4 versions

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and …


AJP Smith, JA Cooper, LK Li, SE Humphries - International Journal of Obesity, 2007 - nature.com
A common polymorphism, rs7566605, 10 kb upstream of the insulin-induced gene 2
transcription start site has been associated with obesity in Caucasian and
African-American populations, with the hypothesis that an alteration in ...
Cited by 29 - Related articles - BL Direct - All 3 versions

High-fat diet, muscular lipotoxicity and insulin resistance


P Schrauwen - Proceedings of the Nutrition Society, 2007 - Cambridge Univ Press
A high dietary fat intake and low physical activity characterize the current
Western lifestyle. Dietary fatty acids do not stimulate their own oxidation and
a surplus of fat is stored in white adipose tissue, liver, heart and ...
Cited by 24 - Related articles - BL Direct - All 5 versions

Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease

- youngbiology.com [PDF] 
AC Gates, C Bernal-Mizrachi, SL Chinault, … - Cell metabolism, 2007 - Elsevier
Age-related disease, not aging per se, causes most morbidity in older humans.
Here we report that skeletal muscle respiratory uncoupling due to UCP1
expression diminishes age-related disease in three mouse models. In a ...
Cited by 10 - Related articles - All 8 versions

[PDF] Regulation of insulin secretion by uncoupling protein


CB Chan, N Kashemsant - Biochemical Society Transactions, 2006 - biochemsoctrans.cn
Abstract UCPs (uncoupling proteins) can regulate cellular ATP production by
uncoupling oxidative phosphoryl- ation. UCP2 is expressed in islet β-cells and
its induction reduces glucose-stimulated insulin secretion. Under ...
Cited by 10 - Related articles - View as HTML - BL Direct - All 5 versions

Inflammation, insulin resistance, and diabetes—Mendelian randomization using CRP …


EJ Brunner, M Kivimäki, DR Witte, DA Lawlor … - PLoS Med, 2008 - medicine.plosjournals.org
We genotyped three tagging SNPs (CRP + 2302G > A; CRP + 1444T > C; CRP + 4899T >
G) in the CRP gene and measured serum CRP in 5,274 men and women at mean ages 49
and 61 y (Whitehall II Study). Homeostasis model assessment-insulin ...
Cited by 10 - Related articles - Cached - All 9 versions

Association between obesity and insulin resistance with UCP2–UCP3 gene variants in …

- unav.es [PDF] 
MC Ochoa, JL Santos, C Azcona, MJ Moreno- … - Molecular Genetics and Metabolism, 2007 - Elsevier
A number of studies have yielded controversial results on the association
between polymorphisms in UCP2 and UCP3 genes with obesity and its comorbidities.
The discrepancy among studies might be partially explained by the lack of ...
Cited by 8 - Related articles - All 3 versions

[PDF] Common adiponectin gene variants show different effects on risk of cardiovascular disease …


DR Gable, J Matin, R Whittall, H Cakmak, KW … - Annals of Human Genetics, 2007 - cardiologicomonzino.it
Alterations in the secretion of adipokines may explain the link between obesity,
type 2 diabetes (T2DM) and coronary artery disease (CAD). These conditions have
been associated with variation in the adiponectin gene, although evidence ...
Cited by 7 - Related articles - View as HTML - BL Direct - All 4 versions

Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine …

- ahajournals.org
A Muthumala, H Montgomery, J Palmen, JA … - Hypertension, 2007 - Am Heart Assoc
The impact of the ACE I/D polymorphism on coronary heart disease (CHD) risk is
modest at most, however it may act as a modifier gene. ACE genotype was
determined in 2711 healthy middle-aged men (mean age 56 years) followed for ...
Cited by 6 - Related articles - All 7 versions


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