- ►oxfordjournals.org H Freeman, RD Cox - Human molecular genetics, 2006 - Oxford Univ Press Diabetes is one of the most challenging health problems of the 21st century with an alarming
increase in the prevalence of type-2 diabetes mellitus (T2DM) and associated conditions such
as hypertension, dyslipidemias and obesity. T2DM is a complex genetic disease ... Cited by 48 - Related articles - BL Direct - All 8 versions
EW Lam, RE Francis, M Petkovic - Biochemical Society …, 2006 - biochemsoctrans.cn Abstract FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function
of FOXO proteins relies on their ability to control diverse and at times, opposing cellular
functions, such as proliferation, differentiation, DNA repair, defence against oxidative ... Cited by 40 - Related articles - View as HTML - BL Direct - All 6 versions
- ►endocrinology-journals.org DA Glauser, W Schlegel - Journal of Endocrinology, 2007 - Soc Endocrinology FOXO transcription factors critically control fundamental cellular processes, including
metabolism, cell differentiation, cell cycle arrest, DNA repair, and other reactions to cellular
stress. FOXO factors sense the balance between stimuli promoting growth and ... Cited by 20 - Related articles - BL Direct - All 2 versions
- ►jbc.org J Buteau, A Shlien, S Foisy, D Accili - Journal of Biological Chemistry, 2007 - ASBMB Diabetes is associated with decreased pancreatic -cell function and mass. It is unclear whether
diabetes treatment should aim at restoring -cell performance/mass or at inducing " -cell rest"
to prevent further deterioration. The transcription factor Foxo1 protects -cells against ... Cited by 20 - Related articles - All 6 versions
SC Martinez, K Tanabe, C Cras-Méneur, NA Abumrad, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Increasing fatty acid concentrations (100–400 μmol/l palmitate or oleate) led to early
Jun NH 2 -terminal kinase (JNK) activation that preceded induction of ER stress markers and
apoptosis. Foxo1 activity was increased with fatty acid administration and by ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►physiology.org K Robertson, Y Lu, K De Jesus, B Li, Q Su, … - American Journal of …, 2008 - Am Physiological Soc Insulin-like growth factor I (IGF-I) is normally produced from hepatocytes and various other cells
and tissues, including the pancreas, and is known to stimulate islet cell replication in vitro, prevent
Fas-mediated β-cell destruction and delay the onset of diabetes in nonobese diabetic ... Cited by 13 - Related articles - BL Direct - All 3 versions
Z Liu, K Tanabe, E Bernal-Mizrachi, MA Permutt - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Glycogen synthase kinase-3 (GSK3) has been implicated in the pathophysiology
of several prevalent diseases, including diabetes. However, despite recent progress in our understanding
of the role of GSK3 in the regulation of glucose metabolism in peripheral tissues, the ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org T Kato, H Shimano, T Yamamoto, M Ishikawa, S … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Incubation of C57BL/6 islets with palmitate caused inhibition of both glucose- and
potassium-stimulated insulin secretion, but addition of eicosapentaenoate (EPA) restored both
inhibitions. Concomitantly, palmitate activated and EPA abolished both mRNA and ... Cited by 11 - Related articles - All 6 versions
KK Ho, SS Myatt, EWF Lam - Oncogene, 2008 - nature.com FoxO transcription factors are an evolutionary conserved subfamily of the forkhead transcription
factors, characterized by the forkhead DNA-binding domain. FoxO factors regulate a number
of cellular processes involved in cell-fate decisions in a cell-type- and ... Cited by 11 - Related articles - BL Direct - All 2 versions
- ►physiology.org TL Jetton, B Everill, J Lausier, V Roskens, … - American Journal of …, 2008 - Am Physiological Soc The physiological mechanisms underlying pancreatic β-cell mass (BCM) homeostasis are complex
and not fully resolved. Here we examined the factors contributing to the increased BCM following
a mild glucose infusion (GI) whereby normoglycemia was maintained through 96 h. We ... Cited by 7 - Related articles - BL Direct - All 3 versions
