- ►diabetesjournals.org JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, … - Diabetes, 2007 - Am Diabetes Assoc Activation of the innate immune system in obesity is a risk factor for the development of type 2
diabetes. The aim of the current study was to investigate the notion that increased numbers of
macrophages exist in the islets of ... Cited by 49 - Related articles - BL Direct - All 11 versions
X Li, L Zhang, S Meshinchi, C Dias-Leme, D Raffin, JD … - Diabetes, 2006 - Am Diabetes Assoc Gene expression profiling of islets from pre-diabetic male Zucker diabetic fatty (ZDF) rats showed
increased expression of hypoxia-related genes, prompting investigation of the vascular integrity of
the islets. The islet ... Cited by 28 - Related articles - BL Direct - All 7 versions
MY Donath, DM Schumann, M Faulenbach, H … - Diabetes Care, 2008 - Am Diabetes Assoc Inflammation is defined as the local response to tissue injury. It is characterized by immune cell
invasion and local release of cytokines and chemokines and is sometimes accompanied by functional or
structural damage of the invaded ... Cited by 20 - Related articles - BL Direct - All 4 versions
MR Hayden, JR Sowers - Antioxidants & Redox Signaling, 2007 - liebertonline.com T YPE 2 DIABETES mellitus (T2DM) has reached pandemic proportions, and current predictions are that
this trend will continue, at least in the near future (1, 71). Even though there has been a vast
amount of new information and ... Cited by 18 - Related articles - BL Direct - All 6 versions
- ►cell.com EJP de Koning, S Bonner-Weir, TJ Rabelink - Trends in Pharmacological …, 2008 - Elsevier Type 2 diabetes is characterized by progressive β-cell dysfunction and a reduction in β-cell mass.
Pancreatic islets are a target for adverse effectors such as high concentrations of glucose,
pro-inflammatory cytokines and ... Cited by 14 - Related articles - All 4 versions
- ►mcponline.org H Lu, Y Yang, EM Allister, N Wijesekara, MB … - Molecular & Cellular …, 2008 - ASBMB Type 2 diabetes (T2D) arises when pancreatic β-cells fail to compensate for systemic insulin
resistance with appropriate insulin secretion. However, the link between insulin resistance and
β-cell failure in T2D is not fully ... Cited by 11 - Related articles - All 7 versions
P Hekerman, J Zeidler, S Korfmacher, S … - BMC Molecular …, 2007 - biomedcentral.com We have used RINm5F insulinoma cells as a model system for a peripheral target cell of leptin. Six
transcripts encoding inflammation-related proteins were found to be upregulated by activation of
LEPRb, namely lipocalin-2, ... Cited by 8 - Related articles - Cached - All 9 versions
- ►numesi.com [PDF] B Portha, G Lacraz, M Kergoat, F Homo-Delarche, … - Molecular and Cellular …, 2009 - Elsevier Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of type 2
diabetes (T2D) mellitus. Nowadays, the debate focuses on the possible mechanisms responsible for
abnormal islet microenvironment, ... Cited by 6 - Related articles - All 3 versions
J Movassat, S Calderari, E Fernández, MA … - Diabetes Obes …, 2007 - interscience.wiley.com Now that reduction in β-cell mass has been clearly established in humans with type 2 diabetes
mellitus (T2D), the debate focuses on the possible mechanisms responsible for decreased β-cell
number. Appropriate inbred rodent ... Cited by 7 - Related articles - All 2 versions
- ►endocrinology-journals.org H Ghanaat-Pour, Z Huang, M Lehtihet, A … - Journal of molecular …, 2007 - Soc Endocrinology The spontaneously diabetic Goto-Kakizaki (GK) rat is frequently used as a model for human type 2
diabetes. Selective loss of glucose-sensitive insulin secretion is an early pathogenetic event in
human type 2 diabetes, and such a ... Cited by 6 - Related articles - All 3 versions
