- ►nih.gov AP Reiner, MJ Barber, Y Guan, PM Ridker, LA … - The American Journal of …, 2008 - Elsevier High basal levels of C-reactive protein predict future cardiovascular disease and metabolic abnormalities
in otherwise healthy adults. Several CRP gene (MIM 123260) polymorphisms are associated
with plasma CRP concentration, 1 but these account for only a small proportion of the ... Cited by 32 - Related articles - All 7 versions
MCT Fyfe, JR White, A Taylor, R Chatfield, E Wargent, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis We evaluated the insulinotropic and anti- hyperglycaemic actions of
glucokinase activators (GKAs), especially through acute and subchronic studies in rodent diabetes
models with (2R)-2-(4-cyclopropanesulphonyl- phenyl)-N-(5-fluorothiazol-2-yl)-3-( ... Cited by 12 - Related articles - BL Direct - All 5 versions
CM García-Herrero, M Galan, O Vincent, B Flandez, M … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Glucokinase (GCK) acts as a glucose sensor in the pancreatic beta
cell and regulates insulin secretion. In the gene encoding GCK the heterozygous mutations that
result in enzyme inactivation cause MODY2. Functional studies of naturally occurring ... Cited by 13 - Related articles - BL Direct - All 5 versions
L Bjorkhaug, J Molnes, O Sovik, PR Njolstad, T … - Journal of biological …, 2007 - ASBMB Running Title: Glucokinase activation and proteasomal degradation ... 1 Address correspondence
to: Torgeir Flatmark, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009
Bergen, Norway. Tel.: +47 55586428; Fax:+ 47 55586360; E-mail: ... Cited by 8 - Related articles - All 6 versions
- ►diabetesjournals.org C Arden, A Trainer, N de la Iglesia, KT Scougall, AL … - Diabetes, 2007 - Am Diabetes Assoc Mutations in the glucokinase (GK) gene cause defects in blood glucose homeostasis. In some
cases (V62M and G72R), the phenotype cannot be explained by altered enzyme kinetics or protein
instability. We used transient and stable expression of green fluorescent protein (GFP) GK ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►jbc.org MF Pino, KA Kim, KD Shelton, J Lindner, S Odili, C … - Journal of Biological …, 2007 - ASBMB To better understand how glucokinase (GK) missense mutations associated with human glycemic
diseases perturb glucose homeostasis, we generated and characterized mice with either an
activating (A456V) or inactivating (K414E) mutation in the gk gene. Animals with these ... Cited by 6 - Related articles - All 7 versions
M Martin, JF Reidhaar-Olson, CM Rondinone - Pharmacogenomics, 2007 - Future Medicine While the genomic era offers great promise for biomedicine in general and for biomarker discovery
in particular, it has yet to significantly impact drug target discovery. Meanwhile, despite improvements
over the past 20 years in reducing attrition in clinical trials due to adverse drug responses, ... Cited by 4 - Related articles - BL Direct - All 5 versions
JV Sagen, L Bjorkhaug, J Molnes, H Ræder, L … - Pediatr …, 2008 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 4 - Related articles - All 3 versions
N Tinto, A Zagari, M Capuano, A De Simone, V … - PLoS ONE, 2008 - pubmedcentral.nih.gov We screened the GCK gene by direct sequencing in 30 patients from South Italy with suspected
MODY. The mutation-induced structural alterations in the protein were analyzed by molecular
modeling. The patients' biochemical, clinical and anamnestic data were obtained. ... Cited by 4 - Related articles - All 6 versions
A Gloyn, N Tribble, M Bunt, A Barrett, P … - Biochemical Society …, 2008 - biochemsoctrans.org There are well-documented examples in the literature of where determining the genetic aetiology
of a disorder has provided insights into important regulatory pathways and protein
interactions, and, more recently, has led to improved treatment options for patients. The ... Cited by 3 - Related articles - Cached - BL Direct - All 5 versions
