- ►nih.gov S Ellard, SE Flanagan, CA Girard, AM Patch, … - The American Journal of Human Genetics, 2007 - Elsevier Heterozygous activating mutations in the KCNJ11 gene encoding the pore-forming
Kir6.2 subunit of the pancreatic beta cell K ATP channel are the most common
cause of permanent neonatal diabetes (PNDM). Patients with PNDM due to a ... Cited by 28 - Related articles - BL Direct - All 9 versions
- ►shouxi.net AI Tarasov, HJ Welters, S Senkel, GU Ryffel, … - Diabetes, 2006 - Am Diabetes Assoc ATP-sensitive K + channels (K ATP channels) couple ß-cell metabolism to
electrical activity and thereby play an essential role in the control of insulin
secretion. Gain-of-function mutations in Kir6.2 (KCNJ11), the pore-forming ... Cited by 17 - Related articles - BL Direct - All 5 versions
- ►shouxi.net R Masia, JC Koster, S Tumini, F Chiarelli, C … - Diabetes, 2007 - Am Diabetes Assoc Mutations in the pancreatic ATP-sensitive K + channel (K ATP channel) cause
permanent neonatal diabetes mellitus (PNDM) in humans. All of the K ATP channel
mutations examined result in decreased ATP inhibition, which in turn is ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►endojournals.org L Aguilar-Bryan, J Bryan - Endocrine Reviews, 2008 - Endocrine Soc An explosion of work over the last decade has produced insight into the multiple
hereditary causes of a nonimmunological form of diabetes diagnosed most
frequently within the first 6 months of life. These studies are providing ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►physiology.org FM Ashcroft - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc This essay is based on a lecture given to the American Physiological Society in
honor of Walter B. Cannon, an advocate of homeostasis. It focuses on the role of
the ATP-sensitive potassium K + (K ATP ) channel in glucose homeostasis ... Cited by 12 - Related articles - BL Direct - All 2 versions
- ►oxfordjournals.org P Proks, K Shimomura, TJ Craig, CAJ Girard, … - Human Molecular Genetics, 2007 - Oxford Univ Press Activating mutations in the genes encoding the ATP-sensitive potassium (K ATP )
channel subunits Kir6.2 and SUR1 are a common cause of neonatal diabetes. Here,
we analyse the molecular mechanism of action of the heterozygous mutation ... Cited by 12 - Related articles - BL Direct - All 4 versions
S Sattiraju, S Reyes, GC Kane, A Terzic - Clinical pharmacology and therapeutics, 2008 - pubmedcentral.nih.gov Pharmacogenomics has established genetic variations in drug-metabolizing
pathways, transporters, receptors, and signaling cascades as critical in
defining pharmacokinetic and/or pharmacodynamic outcomes. 3 A therapeutic ... Cited by 8 - Related articles - All 4 versions
B Jafar-Mohammadi, MI McCarthy - Annals of Medicine, 2008 - Informa Pharma Science Type 2 diabetes (T2D) and obesity are recognized as conditions of growing
biomedical importance to societies worldwide. Despite this, lack of
understanding concerning the processes which normally serve to maintain ... Cited by 6 - Related articles - BL Direct - All 4 versions
I Flechtner, P De Lonlay, M Polak - Diabetes and Metabolism, 2006 - Elsevier ATP-sensitive potassium channels (K ATP ) couple cell metabolism to electrical
activity by regulating potassium movement across the membrane. These channels
are octameric complex with two kind of subunits: four regulatory ... Cited by 5 - Related articles - BL Direct - All 3 versions
AJ Smith, TK Taneja, J Mankouri, A … - Expert Reviews in Molecular Medicine, 2007 - Cambridge Univ Press ATP-sensitivepotassium(K ATP )channelsplayakeyroleintheregulationofinsulin
secretion by coupling glucose metabolism to the electrical activity of
pancreatic b-cells. To generate an electric signal of suitable magnitude, ... Cited by 4 - Related articles - All 2 versions
