Web Images Videos Maps News Shopping Gmail more »
Sign in
Scholar Home  
  Advanced Scholar Search
Scholar Preferences
Scholar Results 1 - 10 of about 16 citing van Poelje: Inhibition of fructose 1, 6-bisphosphatase reduces excessive endogenous glucose.... (0.07 sec) 

Newly approved and promising antidiabetic agents


M Combettes, C Kargar - Therapie, 2007 - edpsciences. org
Abstract – Type 2 diabetes is an endocrine/metabolic disease characterized by
hyperglycemia. It is now well established that insulin resistance and pancreatic
β-cell dysfunction/failure are the two major components of the ...
Cited by 10 - Related articles - All 3 versions

Sources of endogenous glucose production in the Goto–Kakizaki diabetic rat


CM Sena, C Barosa, E Nunes, R Seica, JG … - Diabetes and Metabolism, 2007 - Elsevier
Plasma glucose, insulin and glucose tolerance were quantified in diabetic
Goto–Kakizaki (GK) rats (342 ± 45 g, n = 5) and compared with weight-matched
non-diabetic Wistars (307 ± 30 g, n = 8). Compared to Wistars, GK rats had ...
Cited by 4 - Related articles - BL Direct - All 2 versions

Fructose-1, 6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced …

- diabetesjournals.org
M Kebede, J Favaloro, JE Gunton, DR Laybutt … - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Fructose-1,6-bisphosphatase (FBPase) is a gluconeogenic enzyme that
is upregulated in islets or pancreatic β-cell lines exposed to high fat.
However, whether specific β-cell upregulation of FBPase can impair insulin ...
Cited by 3 - Related articles - All 4 versions

Structures of mammalian and bacterial fructose-1, 6-bisphosphatase reveal the basis for …

- jbc.org
JK Hines, X Chen, JC Nix, HJ Fromm, RB … - Journal of Biological Chemistry, 2007 - ASBMB
Fructose-1,6-bisphosphatase (FBPase) operates at a control point in mammalian
gluconeogenesis, being inhibited synergistically by fructose 2,6-bisphosphate
(Fru-2,6-P 2 ) and AMP. AMP and Fru-2,6-P 2 bind to allosteric and active ...
Cited by 2 - Related articles - All 6 versions

Evolving concepts of type 2 diabetes management with oral medications: new approaches to …


RR Henry - Current Medical Research and Opinion®, 2008 - informahealthcare.com
Background: Type 2 diabetes is often accompanied by co-morbid conditions such as
hypertension and dyslipidemia, which, coupled with persistent hyperglycemia,
result in significant macrovascular and microvascular complications. Type 2 ...
Cited by 2 - Related articles - All 6 versions

Fructose-1, 6-bisphosphatase as a therapeutic target for type 2 diabetes


PD van Poelje, Q Dang, MD Erion - Drug Discovery Today: Therapeutic Strategies, 2007 - Elsevier
Type 2 diabetes mellitus is a metabolic disorder of epidemic proportions that is
characterized by insulin resistance, relative insulin insufficiency, and
increased endogenous glucose production (EGP). These abnormalities underlie ...
Cited by 1 - Related articles

[PDF] Gluconeogenesis as a System: Development of in vivo Flux Analysis of Hepatic Glucose …


JO Alemán, 2007 - dspace.mit.edu
Page 1. Gluconeogenesis as a System: Development of in vivo Flux Analysis of Hepatic
Glucose Production in Type 2 Diabetes By José Orlando Alemán ...
Cited by 1 - Related articles - All 2 versions

Purine inhibitors of fructose-1, 6-bisphosphatase


Q Dang, MD Erion, MR Reddy, ED Robinson, … - US Patent 6,967,193, 2005 - Google Patents
US Patent Nov. 22,2005 Sheet 1 of 10 US 6,967,193 Bl 1) in O .a t_ ra O o *-< ro
X o ro U CL a/ Q. a. ca 0) 10 cfl CL tn fO O O D o -C a. w o O CL isom«rase
Kinase in .u ulase ^ u 2) 4i 5 <3 c; a ^ 4) O <U O Q. O O (A ^ ^ — 0} O ...
Related articles - All 4 versions

Long-term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes …


W Gu, H Yan, KA Winters, R Komorowski, S … - Journal of Pharmacology and Experimental …, 2009 - ASPET
Page 1. JPET #157685 1 Long-term Inhibition of the Glucagon Receptor with
a Monoclonal Antibody in Mice Causes Sustained Improvement ...
Related articles - All 2 versions

Aryl fructose-1, 6-bisphosphatase inhibitors


BC Bookser, Q Dang, KR Reddy - US Patent 7,371,739, 2008 - Google Patents
US 7,371,739 B2 Page 3 Posner, et al. "3-Bromo-2-Pyrone: An Easily Prepared
Chameleon Diene And A Synthetic Equivalent of 2-Pyrone in Thermal Diels- Alder
Cycloadditions," Tetrahedron Lett., 1991, pp. 5295-5298, vol. 39. Puech, et ...
Related articles - All 8 versions


Result Page: 

1

2

Next


 


Go to Google Home - About Google - About Google Scholar

©2009 Google