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Scholar Results 1 - 10 of about 28 citing McCrimmon: Activation of AMP-activated protein kinase within the ventromedial hypothalamus.... (0.14 sec) 

Brain glucose sensing, counterregulation, and energy homeostasis.


N Marty, M Dallaporta, B Thorens - Physiology (Bethesda, Md.), 2007 - ncbi.nlm.nih.gov
Neuronal circuits in the central nervous system play a critical role in orchestrating the control
of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected
by several glucose-sensing units that are located at different anatomical sites and ...
Cited by 22 - Related articles - BL Direct - All 4 versions

AMPK: a metabolic gauge regulating whole-body energy homeostasis

- cell.com
R Lage, C Diéguez, A Vidal-Puig, M López - Trends in Molecular Medicine, 2008 - Elsevier
AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade that
acts as a gauge of cellular energy levels. Over the last few years, accumulating evidence has
demonstrated that AMPK is also involved in the regulation of energy balance at the whole- ...
Cited by 14 - Related articles - All 7 versions

Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food …


M López, CJ Lelliott, A Vidal-Puig - Bioessays, 2007 - interscience.wiley.com
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Cited by 13 - Related articles - BL Direct - All 3 versions

The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes


R McCrimmon - Diabetic Medicine, 2008 - interscience.wiley.com
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Cited by 11 - Related articles - BL Direct - All 3 versions

Key role for AMP-activated protein kinase in the ventromedial hypothalamus in …

- diabetesjournals.org
RJ McCrimmon, M Shaw, X Fan, H Cheng, Y Ding, MC … - Diabetes, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—Using gene silencing technology to selectively downregulate
AMPK in the VMH, a key hypothalamic glucose-sensing region, we demonstrate a key role for
AMPK in the detection of hypoglycemia. In vivo hyperinsulinemic-hypoglycemic (50 mg dl ...
Cited by 12 - Related articles - BL Direct - All 3 versions

Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in …

- physiology.org
DD Canabal, JG Potian, RG Duran, JJ … - American Journal of …, 2007 - Am Physiological Soc
Physiological changes in extracellular glucose, insulin, and leptin regulate glucose-excited
(GE) and glucose-inhibited (GI) neurons in the ventromedial hypothalamus (VMH). Nitric oxide
(NO) signaling, which is involved in the regulation of food intake and insulin signaling, is ...
Cited by 11 - Related articles - BL Direct - All 6 versions

Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the …

- endojournals.org
T Alquier, J Kawashima, Y Tsuji, BB Kahn - Endocrinology, 2007 - Endocrine Soc
Antecedent hypoglycemia blunts counterregulatory responses that normally restore
glycemia, a phenomenon known as hypoglycemia-associated autonomic failure (HAAF). The
mechanisms leading to impaired counterregulatory responses are largely unknown. ...
Cited by 8 - Related articles - BL Direct - All 3 versions

Ventromedial hypothalamic glucokinase is an important mediator of the …


BE Levin, TC Becker, J Eiki, BB Zhang, AA Dunn- … - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—The counterregulatory response to insulin-induced hypoglycemia is mediated
by the ventromedial hypothalamus (VMH), which contains specialized glucosensing
neurons, many of which use glucokinase (GK) as the rate-limiting step in glucose's ...
Cited by 7 - Related articles - BL Direct - All 5 versions

Prior hypoglycemia enhances glucose responsiveness in some ventromedial …

- physiology.org
L Kang, NM Sanders, AA Dunn-Meynell, … - American Journal of …, 2008 - Am Physiological Soc
Antecedent insulin-induced hypoglycemia (IIH) reduces adrenomedullary responses (AMR)
to subsequent bouts of hypoglycemia. The ventromedial hypothalamus [VMH: arcuate (ARC)
+ ventromedial nuclei] contains glucosensing neurons, which are thought to be mediators ...
Cited by 6 - Related articles - BL Direct - All 3 versions

Bringing Light to the Dark Side of Insulin


RS Sherwin - Diabetes, 2008 - Am Diabetes Assoc
My story begins 30 years ago. Bill Tamborlane came to me with a portable, battery-powered
pump being used in pediatrics to infuse the iron-chelating drug desferrioxamine continuously
via the subcutaneous route into children with thalassemia major. He hoped to use it to ...
Cited by 7 - Related articles - All 5 versions


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