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Scholar Results 1 - 10 of about 39 citing Stegenga: Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis.... (0.08 sec) 

Diabetes mellitus as a prothrombotic condition.


PJ Grant - Journal of internal medicine, 2007 - pt.wkhealth.com
Diabetes mellitus (DM) is characterized by fasting hyperglycaemia and a high risk of atherothrombotic
disorders affecting the coronary, cerebral and peripheral arterial trees. The risk of myocardial
infarction (MI) is 3-5 fold higher in Type 2 DM and a DM subject with no history of MI has ...
Cited by 58 - Related articles - BL Direct - All 6 versions

Circulating tissue factor procoagulant activity and thrombin generation in patients …

- endojournals.org
G Boden, VR Vaidyula, C Homko, P Cheung, … - Journal of Clinical …, 2007 - Endocrine Soc
Context: Type 2 diabetes mellitus (T2DM) is a hypercoagulable state. Tissue factor (TF) is the
principal initiator of blood coagulation. ... Objective: Our objective was to examine the effects
of hyperglycemia and hyperinsulinemia on the TF pathway of blood coagulation in T2DM.
Cited by 13 - Related articles - BL Direct - All 3 versions

Hyperglycemia enhances coagulation and reduces neutrophil degranulation, …

- hematologylibrary.org
ME Stegenga, SN van der Crabben, RME … - …, 2008 - bloodjournal.hematologylibrary.org
Type 2 diabetes is associated with altered immune and hemostatic responses. We investigated
the selective effects of hyperglycemia and hyperinsulinemia on innate immune, coagulation,
and fibrinolytic responses during systemic inflammation. Twenty-four healthy humans ...
Cited by 11 - Related articles - All 7 versions

Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene …


ME Stegenga, SN van der Crabben, MC … - Diabetic …, 2008 - pubmedcentral.nih.gov
Hyperglycaemia reduced LPS-induced mRNA expression of nuclear factor of κ light polypeptide
gene enhancer in B cells inhibitor alpha (NFKBIA), interleukin-1 alpha (IL1A) and chemokine
(CC motif) ligand 3 (CCL3), whereas during hyperinsulinaemia enhanced mRNA levels ...
Cited by 11 - Related articles - BL Direct - All 9 versions

Optimization of glucose level to determine the stimulation index of isolated rat islets


N Sakata, S Egawa, S Sumi, M Unno - Pancreas, 2008 - journals.lww.com
Methods: We isolated islets of 3 rat strains (Lewis, Sprague- Dawley, and WistarVn = 5 per
strain) and measured the viability of the islets. We measured the amount of insulin released after
high and low glucose stimulation. The SI was calculated as a ratio of the insulin value ...
Cited by 6 - Related articles - BL Direct - All 4 versions

Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma …

- physiology.org
RME Blumer, SN van der Crabben, ME … - American Journal of …, 2008 - Am Physiological Soc
Adiponectin is a fat-derived hormone with insulin-sensitizing properties. In patients with type
2 diabetes plasma adiponectin levels are decreased. Since these patients are characterized
by high plasma insulin and glucose concentrations, hyperinsulinemia and hyperglycemia ...
Cited by 6 - Related articles - All 3 versions

Effect of insulin therapy on coagulation and fibrinolysis in medical intensive care …

- prsjournal.net
L Langouche, W Meersseman, SV Perre, I … - Critical care …, 2008 - journals.lww.com
Objective: Most intensive care deaths beyond the first few days of critical illness are attributable
to nonresolving organ failure, either due to or coinciding with sepsis. One of the mechanisms
that is thought to contribute to the pathogenesis of organ failure is microvascular ...
Cited by 6 - Related articles - BL Direct - All 14 versions

Metabolic syndrome and resistance to IV thrombolysis in middle cerebral artery …

- nursing2008.com
JF Arenillas, L Ispierto, M Millan, D Escudero, N Perez … - Neurology, 2008 - AAN Enterprises
Results: Fifty-eight (58%) patients fulfilled MetS criteria. Median prebolus NIH Stroke Scale score
was 17. Forty (42%) patients showed resistance to clot dissolution, and 53 (53%) had poor clinical
outcomes (mRS > 2). A multivariable-adjusted logistic regression model identified MetS ...
Cited by 8 - Related articles - All 6 versions

Challenges for modeling and interpreting the complex biology of severe injury and …

- highwire.org
SF Lowry, SE Calvano - Journal of Leukocyte Biology, 2008 - jleuk.highwire.org
Human injury is associated with inflammatory responses that are modulated by the acute and
chronic activity of endogenous factors and exogenous interventions. A characteristic feature
of chronic, severe inflammatory states is the diminished signal output variability of many ...
Cited by 5 - Related articles - BL Direct - All 6 versions

The effects of decreasing low-molecular weight hemoglobin components of …

- prsjournal.com
J Rice, N Philbin, R Light, F Arnaud, T … - The Journal of …, 2008 - journals.lww.com
No NMRC authors have financial or other competing interests related to this article. HBOC formulations
were provided by Biopure Corp. under a Materials Transfer Agreement. There were no transfers
of funds in any of these agreements. Drs. P. Moon, V. Rentko, and LB Pearce are Biopure ...
Cited by 5 - Related articles - BL Direct - All 6 versions


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