- ►nih.gov AS Slingerland - Reviews in Endocrine & Metabolic Disorders, 2006 - Springer Abstract Monogenic diabetes results from one or more mutations in a single gene which might
hence be rare but has great impact leading to diabetes at a very young age. It has resulted in
great challenges for researchers elucidating the aetiology of diabetes and related ... Cited by 12 - Related articles - BL Direct - All 6 versions
- ►nih.gov S Ellard, C Bellanne-Chantelot, AT Hattersley - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Mutations in the GCK and HNF1A genes are the most common cause
of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes
the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations ... Cited by 17 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org J Ek, SP Hansen, M Lajer, C Nicot, TW Boesgaard, S … - Diabetes, 2006 - Am Diabetes Assoc Recently, it has been shown that mutations in the P2 promoter of the hepatocyte nuclear factor
(HNF)-4α gene (HNF4A) cause maturity-onset diabetes of the young (MODY), while single nucleotide
polymorphisms in this locus are associated with type 2 diabetes. In this study, we ... Cited by 12 - Related articles - BL Direct - All 6 versions
DM Lehman, DK Richardson, CP Jenkinson, KJ Hunt, … - Diabetes, 2007 - Am Diabetes Assoc Common and rare variants of the hepatocyte nuclear factor 4α (HNF4A) gene have been associated
with type 2 diabetes and related traits in several populations suggesting the involvement of this
transcription factor in diabetes pathogenesis. Single nucleotide polymorphisms (SNPs) ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LW Harries, JM Locke, B Shields, NA Hanley, KP … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—HNF4A was expressed exclusively from the P2 promoter in adult pancreas, but from
9 weeks until at least 26 weeks after conception, up to 23% of expression in fetal pancreas was
of P1 origin. HNF4A4–6 transcripts were not detected in any tissue. In whole pancreas, ... Cited by 9 - Related articles - All 6 versions
L Love-Gregory, MA Permutt - Current Opinion in Clinical Nutrition & …, 2007 - journals.lww.com Purpose of review: Variants in the hepatocyte nuclear factor 4α (HNF4A) gene play a role in the
development of diabetes mellitus. Although genetic variation in and around HNF4A regulatory
regions has received considerable attention, the significance of these variants in the ... Cited by 6 - Related articles - BL Direct - All 5 versions
JV Sagen, L Bjorkhaug, J Molnes, H Ræder, L … - Pediatr …, 2008 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 4 - Related articles - All 3 versions
LW Harries - Expert Review of Endocrinology and Metabolism, 2006 - ingentaconnect.com Variation in mRNA processing has the capacity to exert fine control over gene expression in
most cell types. The hepatic nuclear factor genes, like approximately 74% of the genome, produce
multiple transcripts. Hepatic nuclear factor isoforms exhibit both spatial and temporal ... Cited by 3 - Related articles - All 3 versions
MN Weedon, TM Frayling - Current Diabetes Reports, 2007 - Springer Introduction Maturity-onset diabetes of the young (MODY) is a type of non–insulin-dependent
diabetes mellitus caused by rare autosomal-dominant mutations, accounting for 1% to 2% of
diabetes cases. Patients with MODY usually pres- ent before the age of 25 and often have ... Cited by 2 - Related articles - BL Direct - All 2 versions
S Johansson, H Ræder, SÅ Eide, K Midthjell, K Hveem, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— Recent publications have found an association between common variants near
the hepatocyte nuclear factor 4α (HNF4A) P2 promoter and type 2 diabetes in some populations
but not in others, and the role for HNF4A in type 2 diabetes has remained unclear. In an ... Cited by 2 - Related articles - BL Direct - All 3 versions
