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Scholar Results 1 - 10 of about 19 citing Zelent: A glucose sensor role for glucokinase in anterior pituitary cells. (0.08 sec) 

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, …

- diabetesjournals.org
D Johnson, RM Shepherd, D Gill, T Gorman, … - Diabetes, 2007 - Am Diabetes Assoc
Because glucokinase is a metabolic sensor involved in the regulated release of
insulin, we have investigated the acute actions of novel glucokinase activator
compound 50 (GKA50) on islet function. Insulin secretion was determined by ...
Cited by 15 - Related articles - BL Direct - All 6 versions

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic …


MCT Fyfe, JR White, A Taylor, R Chatfield, E … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis We evaluated the insulinotropic and anti-
hyperglycaemic actions of glucokinase activators (GKAs), especially through
acute and subchronic studies in rodent diabetes models with (2R)-2-(4- ...
Cited by 12 - Related articles - BL Direct - All 5 versions

Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory …

- yale.edu [PDF] 
BE Levin, TC Becker, J Eiki, BB Zhang, AA … - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—The counterregulatory response to insulin-induced hypoglycemia is
mediated by the ventromedial hypothalamus (VMH), which contains specialized
glucosensing neurons, many of which use glucokinase (GK) as the ...
Cited by 7 - Related articles - BL Direct - All 5 versions

Cell Biology Assessment of Glucokinase Mutations V62M and G72R in Pancreatic β-Cells

- diabetesjournals.org
C Arden, A Trainer, N de la Iglesia, KT … - Diabetes, 2007 - Am Diabetes Assoc
Mutations in the glucokinase (GK) gene cause defects in blood glucose
homeostasis. In some cases (V62M and G72R), the phenotype cannot be explained by
altered enzyme kinetics or protein instability. We used transient and ...
Cited by 7 - Related articles - BL Direct - All 4 versions

Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and …

- jhc.org
RL Sorenson, LE Stout, TC Brelje, TL Jetton, … - Journal of Histochemistry and Cytochemistry, 2007 - Histochemical Soc
PITUITARY HORMONES exert extensive and profound influences on fuel homeostasis,
energy metabolism, growth, and reproduction of the organism. The regulation of
synthesis and secretion of these hormones is widely accepted to be ...
Cited by 7 - Related articles - BL Direct - All 5 versions

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for …

- jbc.org
MF Pino, KA Kim, KD Shelton, J Lindner, S … - Journal of Biological Chemistry, 2007 - ASBMB
To better understand how glucokinase (GK) missense mutations associated with
human glycemic diseases perturb glucose homeostasis, we generated and
characterized mice with either an activating (A456V) or inactivating ...
Cited by 6 - Related articles - All 7 versions

Glucokinase activators for the potential treatment of type 2 diabetes


J Grimsby, SJ Berthel, R Sarabu - Current Topics in Medicinal Chemistry, 2008 - ingentaconnect.com
Page 1. 1524 Current Topics in Medicinal Chemistry, 2008, 8, 1524-1532
1568-0266/08 $55.00+.00 © 2008 Bentham Science Publishers Ltd. ...
Cited by 5 - Related articles - All 4 versions

Fasting and glucose effects on pituitary leptin expression: is leptin a local signal for nutrient …

- jhc.org
C Crane, N Akhter, BW Johnson, M … - Journal of Histochemistry and Cytochemistry, 2007 - Histochemical Soc
LEPTIN IS A PRODUCT of the Ob gene that regulates satiety as well as energy
expenditure (Rowland et al. 1996 Go ). Its presence was initially discovered in
adipose tissue (Zhang et al. 1994 Go ), and it was first thought to be an ...
Cited by 4 - Related articles - BL Direct - All 5 versions

Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout …


T Gorman, DC Hope, R Brownlie, A Yu, D Gill … - Diabetes, Obesity and Metabolism, 2008 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to
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degraded, the site should continue to be functional. We recommend using the ...
Cited by 4 - Related articles - All 3 versions

Negative energy balance increases periprandial ghrelin and growth hormone concentrations …


BJ Bradford, MS Allen - Domestic Animal Endocrinology, 2008 - Elsevier
The reported effects of feeding on growth hormone (GH) secretion in ruminants
have been inconsistent, and are likely influenced by energy status of animals.
High-producing dairy cows in early lactation and late lactation were used ...
Cited by 3 - Related articles - All 4 versions


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