TP Di Lorenzo, M Peakman, BO Roep - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov T cell epitopes represent the molecular code words through which the adaptive
immune system communicates. In the context of a T cell-mediated autoimmune
disease such as type 1 diabetes, CD4 and CD8 T cell recognition of islet ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►nih.gov M Nakayama, JN Beilke, JM Jasinski, M … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig NOD mice with knockout of both native insulin genes and a mutated proinsulin
transgene, alanine at position B16 in preproinsulin (B16:A-dKO mice), do not
develop diabetes. Transplantation of NOD islets, but not bone marrow, ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org MG Levisetti, A Suri, SJ Petzold, ER Unanue - The Journal of Immunology, 2007 - Am Assoc Immnol Several naturally occurring anti-insulin CD4 T cells were isolated from islet
infiltrates of NOD mice. In accordance with the results of others, these T cells
recognized the segment of the -chain from residues 9–23. Peptides ... Cited by 10 - Related articles - All 5 versions
MM Martinic, MG von Herrath - Immunological Reviews, 2008 - interscience.wiley.com Summary: Type 1 diabetes (T1D) is the most common autoimmune disease affecting
almost 20 million people worldwide. T1D is thought to be caused by
autoaggressive T cells infiltrating pancreatic islets and destroying ... Cited by 6 - Related articles - BL Direct - All 3 versions
AR Burton, E Vincent, PY Arnold, GP Lennon, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Neither GAD- nor IA2-specific TCRs mediated T-cell islet infiltration
or diabetes even though T-cells developed in these Rg mice and responded to
their cognate epitope. IA2β/phogrin and insulin-specific Rg T-cells ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org Y Kang, L Xu, B Wang, A Chen, G Zheng - The Journal of Immunology, 2008 - Am Assoc Immnol Vaccination for autoimmune and alloimmune diseases has long been an attractive
idea. Yet, there is no suitable adjuvant to forcefully steer the immune response
toward tolerance. In this study we show that dexamethasone, a potent ... Cited by 4 - Related articles - All 6 versions
- ►highwire.org DM Waid, GM Vaitaitis, ND Pennock, DH … - Journal of Leukocyte Biology, 2008 - jleuk.highwire.org Although regulatory T cells (Tregs) are well described, identifying
autoaggressive effector T cells has proven more difficult. However, we
identified CD4 lo CD40 + (Th40) cells as being necessary and sufficient for ... Cited by 5 - Related articles - All 7 versions
- ►pnas.org M Kobayashi, J Jasinski, E Liu, M Li, D Miao … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences A fundamental question is what are the molecular determinants that lead to
spontaneous preferential targeting of specific autoantigens in autoimmune
diseases, such as the insulin B:9–23 peptide sequence in type 1 diabetes. ... Cited by 3 - Related articles - All 5 versions
C Papewalis, M Wuttke, J Seissler, Y Meyer, … - Clinical Cancer Research, 2008 - AACR Results: Lymph nodes from control protein-immunized mice did not show any
macroscopic abnormalities, whereas tumor peptide-treated mice revealed in
general profoundly enlarged lymph nodes. In tetramer analysis of ... Cited by 1 - Related articles - All 3 versions
- ►endojournals.org M Wuttke, C Papewalis, Y Meyer, C Kessler, … - Endocrinology, 2008 - Endocrine Soc Up to now, no relevant tumor antigen has been identified in medullary thyroid
carcinoma (MTC). The aim of the present study was to prove the concept of an
immunization with an amino acid-modified calcitonin (CT) for the treatment ... Cited by 1 - Related articles - All 3 versions
