- ►nih.gov YC Long, JR Zierath - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and
lipid oxidation to produce energy, while turning off energy-consuming processes ... Cited by 166 - Related articles - BL Direct - All 9 versions
- ►ahajournals.org MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that
is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused
by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose ... Cited by 164 - Related articles - All 7 versions
- ►diabetesjournals.org A Sriwijitkamol, DK Coletta, E Wajcberg, GB Balbontin, … - Diabetes, 2007 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) by exercise induces several cellular processes
in muscle. Exercise activation of AMPK is unaffected in lean (BMI ∼25 kg/m 2 ) subjects with
type 2 diabetes. However, most type 2 diabetic subjects are obese (BMI >30 kg/m 2 ), and ... Cited by 51 - Related articles - BL Direct - All 4 versions
SB Jørgensen, EA Richter, JFP … - The Journal of …, 2006 - Physiological Soc The 5′-AMP-activated protein kinase (AMPK) is a potent regulator of skeletal muscle metabolism
and gene expression. AMPK is activated both in response to in vivo exercise and ex vivo
contraction. AMPK is therefore believed to be an important signalling molecule in ... Cited by 47 - Related articles - BL Direct - All 9 versions
- ►cell.com H Sano, L Eguez, MN Teruel, M Fukuda, TD Chuang, … - Cell Metabolism, 2007 - Elsevier GLUT4 trafficking to the plasma membrane of muscle and fat cells is regulated by insulin. An
important component of insulin-regulated GLUT4 distribution is the Akt substrate AS160 rab
GTPase-activating protein. Here we show that Rab10 functions as a downstream target of ... Cited by 44 - Related articles - All 7 versions
FSL Thong, PJ Bilan, A Klip - Diabetes, 2007 - Am Diabetes Assoc Insulin-dependent phosphorylation of Akt target AS160 is required for GLUT4 translocation. Insulin
and platelet-derived growth factor (PDGF) (Akt activators) or activation of conventional/novel
(c/n) protein kinase C (PKC) and 5′ AMP-activated protein kinase (AMPK) all promote a ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►uidaho.edu [PDF] DJ O'Gorman, HKR Karlsson, S McQuaid, O Yousif, Y … - Diabetologia, 2006 - Springer Page 1. ARTICLE Exercise training increases insulin-stimulated glucose disposal and GLUT4
(SLC2A4) protein content in patients with type 2 diabetes DJ O'Gorman & HKR Karlsson &
S. McQuaid & O. Yousif & Y. Rahman & D. Gasparro & S. Glund & ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►jbc.org A Tzatsos, PN Tsichlis - Journal of Biological Chemistry, 2007 - ASBMB Energy depletion activates AMP-activated protein kinase (AMPK) and inhibits cell growth via
TSC2-dependent suppression of mTORC1 signaling. Long term energy depletion also induces
apoptosis by mechanisms that are not well understood to date. Here we show that AMPK, ... Cited by 32 - Related articles - All 5 versions
EB Taylor, D An, HF Kramer, H Yu, NL Fujii, KSC … - Journal of Biological …, 2008 - ASBMB The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS) motifs in response
to insulin and contraction in skeletal muscle, regulating glucose uptake. Here we discovered
a dissociation between AS160 protein expression and apparent AS160 PAS ... Cited by 34 - Related articles - All 6 versions
KM Geraghty, S Chen, JE Harthill, AF … - The Biochemical …, 2007 - pubmedcentral.nih.gov AS160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4)
translocation, but is widely expressed in insulin-insensitive tissues lacking GLUT4. Having isolated
AS160 by 14-3-3-affinity chromatography, we found that binding of AS160 to 14-3-3 ... Cited by 28 - Related articles - BL Direct - All 6 versions
