- ►ahajournals.org MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular
energy status that is conserved in all eukaryotic cells. It is activated by
increases in the cellular AMP:ATP ratio caused by metabolic stresses that ... Cited by 164 - Related articles - All 7 versions
HF Kramer, CA Witczak, EB Taylor, N Fujii, … - Journal of Biological Chemistry, 2006 - ASBMB Insulin and contraction are potent stimulators of GLUT4 translocation and
increase skeletal muscle glucose uptake. We recently identified the Rab
GTPase-activating protein (GAP) AS160 as a putative point of convergence ... Cited by 64 - Related articles - All 6 versions
- ►diabetesjournals.org A Sriwijitkamol, DK Coletta, E Wajcberg, GB … - Diabetes, 2007 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) by exercise induces several
cellular processes in muscle. Exercise activation of AMPK is unaffected in lean
(BMI ∼25 kg/m 2 ) subjects with type 2 diabetes. However, most type 2 ... Cited by 51 - Related articles - BL Direct - All 4 versions
- ►physiology.org N Fujii, N Jessen, LJ Goodyear - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc The AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is
activated by acute increases in the cellular [AMP]/[ATP] ratio. In skeletal
and/or cardiac muscle, AMPK activity is increased by stimuli such as ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►cell.com H Sano, L Eguez, MN Teruel, M Fukuda, TD … - Cell Metabolism, 2007 - Elsevier GLUT4 trafficking to the plasma membrane of muscle and fat cells is regulated by
insulin. An important component of insulin-regulated GLUT4 distribution is the
Akt substrate AS160 rab GTPase-activating protein. Here we show that Rab10 ... Cited by 44 - Related articles - All 7 versions
FSL Thong, PJ Bilan, A Klip - Diabetes, 2007 - Am Diabetes Assoc Insulin-dependent phosphorylation of Akt target AS160 is required for GLUT4
translocation. Insulin and platelet-derived growth factor (PDGF) (Akt
activators) or activation of conventional/novel (c/n) protein kinase C ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►jbc.org A Tzatsos, PN Tsichlis - Journal of Biological Chemistry, 2007 - ASBMB Energy depletion activates AMP-activated protein kinase (AMPK) and inhibits cell
growth via TSC2-dependent suppression of mTORC1 signaling. Long term energy
depletion also induces apoptosis by mechanisms that are not well understood ... Cited by 32 - Related articles - All 5 versions
EB Taylor, D An, HF Kramer, H Yu, NL Fujii, … - Journal of Biological Chemistry, 2008 - ASBMB The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS)
motifs in response to insulin and contraction in skeletal muscle, regulating
glucose uptake. Here we discovered a dissociation between AS160 protein ... Cited by 34 - Related articles - All 6 versions
DG Hardie - FEBS letters, 2008 - Elsevier Obesity, type 2 diabetes and the metabolic syndrome are disorders of energy
balance, which the AMP-activated protein kinase (AMPK) regulates both at the
cellular and whole body levels. AMPK switches cells from an anabolic state ... Cited by 33 - Related articles - All 11 versions
KM Geraghty, S Chen, JE Harthill, AF … - The Biochemical Journal, 2007 - pubmedcentral.nih.gov AS160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose
transporter 4) translocation, but is widely expressed in insulin-insensitive
tissues lacking GLUT4. Having isolated AS160 by 14-3-3-affinity ... Cited by 28 - Related articles - BL Direct - All 6 versions
