- ►jimmunol.org S Wan, C Xia, L Morel - The Journal of Immunology, 2007 - Am Assoc Immnol The B6.Sle1.Sle2.Sle3 triple congenic mouse (B6.TC) is a model of lupus coexpressing the three
major NZM2410-derived susceptibility loci on a C57BL/6 background. B6.TC mice produce high
titers of antinuclear nephrogenic autoantibodies and a highly penetrant ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►endojournals.org R Bouillon, G Carmeliet, L Verlinden, E van Etten, A … - Endocrine …, 2008 - Endocrine Soc The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin
D [1,25-(OH) 2 D], can now be better evaluated by critical analysis of mice with ... Cited by 35 - Related articles - All 6 versions
RJ Mellanby, D Thomas, JM Phillips, A Cooke - Immunology, 2007 - pubmedcentral.nih.gov The role of regulatory T cells (Tregs) in maintaining self tolerance has been intensively researched
and there is a growing consensus that a decline in Treg function is an important step towards
the development of autoimmune diseases, including diabetes. Although we show here ... Cited by 27 - Related articles - BL Direct - All 7 versions
- ►jimmunol.org S Gaudreau, C Guindi, M Menard, G Besin, G … - The Journal of …, 2007 - Am Assoc Immnol Autoimmune diabetes results from a breakdown of self-tolerance that leads to T cell-mediated
-cell destruction. Abnormal maturation and other defects of dendritic cells (DCs) have been associated
with the development of diabetes. Evidence is accumulating that self-tolerance can be ... Cited by 20 - Related articles - All 3 versions
J Peng, B Dicker, W Du, F Tang, P Nguyen, T Geiger, … - Journal of Autoimmunity, 2007 - Elsevier Immuno-regulatory defects, including a reduction in the number and function of regulatory T
cells, play an important role in the development of autoimmune diabetes in both humans and
non-obese diabetic (NOD) mice. In this study we tested the effect of introduction of FoxP3 ... Cited by 17 - Related articles - All 4 versions
- ►nih.gov M Feuerer, W Jiang, PD Holler, A … - Proceedings of the …, 2007 - National Acad Sciences FoxP3 + CD4 + regulatory T cells (Tregs) play a key role in the maintenance of peripheral
self-tolerance, and it has been suggested that diabetes-susceptible nonobese diabetic
(NOD) mice are defective in the generation and numbers of Tregs. We found thymic ... Cited by 17 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org CM Cuda, S Wan, ES Sobel, BP Croker, L … - The Journal of …, 2007 - Am Assoc Immnol The Sle1 locus is a key determinant of lupus susceptibility in the NZM2410 mouse model. Within
Sle1, we have previously shown that Sle1a expression enhances activation levels and effector
functions of CD4 + T cells and reduces the size of the CD4 + CD25 + Foxp3 + regulatory T ... Cited by 12 - Related articles - All 2 versions
C Gysemans, E van Etten, L Overbergh, A Giulietti, G … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— VDR −/− NOD mice are rachitic and have lower numbers of putative regulator cells
[TCR-α/β + CD4 − CD8 − (natural killer T-cells) and CD4 + CD25 + T-cells [in central and peripheral
immune organs compared with VDR +/+ NOD littermates. Lipopolysaccharide-stimulated ... Cited by 10 - Related articles - BL Direct - All 8 versions
SD Burke, H Dong, AD Hazan, BA Croy - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Pregnant diabetic women are at a 4–12 times higher risk for preeclampsia, an
urgent acute-onset complication of mid- to late gestation, than normal pregnant women. Hallmarks
of preeclampsia are hypertension, proteinuria, and incomplete modification of ... Cited by 9 - Related articles - BL Direct - All 4 versions
- ►pnas.org AM D'Alise, V Auyeung, M Feuerer, J … - Proceedings of the …, 2008 - National Acad Sciences FoxP3 + regulatory T cells (Tregs) protect against autoimmunity, type 1 diabetes (T1D) in
particular, prompting the hypothesis that a deficiency in Tregs is a critical determinant of diabetes
susceptibility in NOD mice. However, tests of this hypothesis have yielded contradictory ... Cited by 9 - Related articles - All 7 versions
