PC Butler, JJ Meier, AE Butler, A Bhushan - Nature clinical practice. …, 2007 - ncbi.nlm.nih.gov Replication of beta cells is an important source of beta-cell expansion in early childhood. The
recent linkage of type 2 diabetes with several transcription factors involved in cell cycle regulation
implies that growth of the beta-cell mass in early childhood might be an important ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin secretion, loss
of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet amyloid is derived
from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted with ... Cited by 28 - Related articles - BL Direct - All 4 versions
JA Williamson, AD Miranker - … A Publication of the Protein Society, 2007 - pubmedcentral.nih.gov The protein islet amyloid polypeptide (IAPP) is a glucose metabolism associated hormone cosecreted
with insulin by the β-cells of the pancreas. In humans with type 2 diabetes, IAPP deposits as
amyloid fibers. The assembly intermediates of this process are associated with β-cell ... Cited by 25 - Related articles - BL Direct - All 7 versions
JJ Meier, AE Butler, Y Saisho, T Monchamp, R Galasso … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Little is known about the capacity, mechanisms, or timing of growth in β-cell mass
in humans. We sought to establish if the predominant expansion of β-cell mass in humans occurs
in early childhood and if, as in rodents, this coincides with relatively abundant β-cell ... Cited by 23 - Related articles - All 3 versions
MR Hayden, JR Sowers - Antioxidants & Redox Signaling, 2007 - liebertonline.com T YPE 2 DIABETES mellitus (T2DM) has reached pandemic proportions, and current predictions
are that this trend will continue, at least in the near future (1, 71). Even though there has been
a vast amount of new information and treat- ments made available during the past ... Cited by 18 - Related articles - BL Direct - All 6 versions
- ►endojournals.org M Salehi, BA Aulinger, DA D'Alessio - Endocrine Reviews, 2008 - Endocrine Soc THE LAST TWO DECADES have seen a major shift in the consensus on the pathogenesis of
type 2 diabetes mellitus (T2DM). Although it is clear that resistance of peripheral tissues to insulin
is an abnormality common to almost all patients with T2DM, the centrality of β-cell ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►geyseco.info [PDF] JJ Meier - Diabetologia, 2008 - Springer Abstract Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement
of beta cell function is therefore the logical long-term solution to therapy. This review sets out
to describe the defects in beta cell mass and function in both forms of diabetes, summa- ... Cited by 16 - Related articles - BL Direct - All 6 versions
- ►nih.gov IT Yonemoto, GJA Kroon, HJ Dyson, WE Balch, JW … - Biochemistry, 2008 - pubs.acs.org Human amylin, or islet amyloid polypeptide, is a peptide cosecreted with insulin by the beta cells
of the pancreatic islets of Langerhans. The 37-residue, C-terminally amidated human amylin
peptide derives from a proprotein that undergoes disulfide bond formation in the ... Cited by 11 - Related articles - All 5 versions
- ►physiology.org C Huang, L Haataja, T Gurlo, AE Butler, X … - American Journal of …, 2007 - Am Physiological Soc The islet in type 2 diabetes is characterized by an 60% β-cell deficit, increased β-cell
apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). Human IAPP
(hIAPP) but not rodent IAPP (rIAPP) forms toxic oligomers and amyloid fibrils in an ... Cited by 10 - Related articles - BL Direct - All 3 versions
