C Postic, J Girard - The Journal of clinical investigation, 2008 - pubmedcentral.nih.gov Nonalcoholic fatty liver disease (NAFLD) is gaining increasing recognition as a component of
the epidemic of obesity in the United States as well as in other parts of the world. NAFLD is the
most common cause of liver dysfunction and affects close to 20 million patients in the US ... Cited by 50 - Related articles - BL Direct - All 6 versions
SA Harrison, CP Day - British Medical Journal, 2007 - gut.bmj.com Compared with our ancestors, Western societies today lead a lifestyle that is much more
sedentary, probably as a result of cultural changes stemming from modern socio-economic
morays. Taking into account differences in body size, our energy expenditure per ... Cited by 40 - Related articles - BL Direct - All 3 versions
… Denechaud, P Bossard, JMA Lobaccaro, L … - The Journal of …, 2008 - pubmedcentral.nih.gov The transcription factor carbohydrate-responsive element–binding protein (ChREBP) has emerged
as a central regulator of lipid synthesis in liver because it is required for glucose-induced expression
of the glycolytic enzyme liver–pyruvate kinase (L-PK) and acts in synergy with SREBP to ... Cited by 32 - Related articles - BL Direct - All 6 versions
M Lafontan, PV Piazza, J Girard - Diabetes and Metabolism, 2007 - Elsevier Clinical reports (RIO trials) have shown that chronic administration of a CB-cannabinoid receptor
antagonist (rimonabant) provides improvements of disturbed metabolic parameters observed
in overweight and obese patients with type 2 diabetes. The production of ... Cited by 24 - Related articles - BL Direct - All 4 versions
- ►cell.com F Guo, DR Cavener - Cell Metabolism, 2007 - Elsevier Metabolic adaptation is required to cope with episodes of protein deprivation and
malnutrition. GCN2 eIF2α kinase, a sensor of amino acid deficiency, plays a key role in yeast
and mammals in modulating amino acid metabolism as part of adaptation to nutrient ... Cited by 22 - Related articles - All 9 versions
DPY Koonen, RL Jacobs, M Febbraio, ME Young, CLM … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—The etiology of type 2 diabetes often involves diet-induced obesity (DIO), which
is associated with elevated plasma fatty acids and lipoprotein associated triglycerides. Since
aberrant hepatic fatty acid uptake may contribute to this, we investigated whether ... Cited by 16 - Related articles - BL Direct - All 4 versions
N Stefan, K Kantartzis, HU Haring - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes and cardiovascular disease represent a serious threat to the health of the population
worldwide. Although overall adiposity and particularly visceral adiposity are established risk
factors for these diseases, in the recent years fatty liver emerged as an additional and ... Cited by 15 - Related articles - All 4 versions
MN Davies, BL O'Callaghan, HC Towle - Journal of Biological Chemistry, 2008 - ASBMB Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription
factor that activates genes involved in de novo lipogenesis in mammals. The current model for
glucose activation of ChREBP proposes that increased glucose metabolism triggers a ... Cited by 11 - Related articles - All 5 versions
C Ji - Journal of gastroenterology and hepatology, 2008 - pubmedcentral.nih.gov J Gastroenterol Hepatol. Author manuscript; available in PMC 2008 July 30. ... J Gastroenterol
Hepatol. 2008 March; 23(Suppl 1): S16–S24. ... Cheng Ji, USC-UCLA Research Center for Alcoholic
Liver and Pancreatic Diseases, USC Research Center for Liver Disease, Department of ... Cited by 12 - Related articles - BL Direct - All 5 versions
