E Kroon, LA Martinson, K Kadoya, AG Bang, … - Nature biotechnology, 2008 - novocell.com Development of a cell therapy for diabetes would be greatly aided by a renewable
supply of human ß-cells. Here we show that pancreatic endoderm derived from
human embryonic stem (hES) cells efficiently generates glucose-responsive ... Cited by 132 - Related articles - View as HTML - BL Direct - All 10 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet
amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►nih.gov V Hook, L Funkelstein, D Lu, S Bark, J …, 2008 - Annual Reviews Peptide neurotransmitters and peptide hormones, collectively known as
neuropeptides, are required for cell-cell communication in neurotransmission and
for regulation of endocrine functions. Neuropeptides are synthesized from ... Cited by 26 - Related articles - BL Direct - All 7 versions
F Johan… - Experimental Diabetes Research, 2008 - hindawi.com Amyloid formation is cytotoxic and can activate the caspase cascade. Here, we
monitor caspase-3-like activity as reduction of fluorescence resonance energy
transfer (FRET) using the contstruct pFRET2-DEVD containing enhanced cyan ... Cited by 6 - Related articles - Cached - All 8 versions
- ►diabetesjournals.org L Marzban, A Tomas, TC Becker, L Rosenberg, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Thioflavine S–positive amyloid deposits were clearly present after
10 days of culture. Transduction with Ad-hProIAPP-siRNA reduced proIAPP
expression by 75% compared with nontransduced islets as assessed by Western ... Cited by 5 - Related articles - All 3 versions
AM Davalli, L Perego, F Bertuzzi, G Finzi, S … - Cell Transplantation, 2008 - ingentaconnect.com To learn more about nonimmune-mediated islet graft failure, we transplanted
different preparations (preps) of isolated human islets under the kidney capsule
of streptozotocin (STZ)-diabetic nude mice. One month after the ... Cited by 1 - Related articles
R Guardado-Mendoza, AM Davalli, AO Chavez, … - Proceedings of the National Academy of Sciences, 2009 - vietwebdisk.com Type-2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by
insulin resistance in liver, muscle, and adipose tissue, as well as progressive
β-cell dysfunction leading to hyperglycemia (1–3). Hyperglycemia and ... Cited by 1 - Related articles - All 7 versions
Y Zhang, F Ranta, C Tang, E Shumilina, H … - Apoptosis, 2009 - Springer Abstract Amyloid peptides interfere with survival of pancreatic beta-cells. In
some cells apoptosis is paralleled by ceramide-dependent alterations of ion
channel activity. The purpose of the present study was to elucidate the ... Related articles - All 2 versions
A Arne, B Sara, H LA… - Experimental Diabetes Research, 2009 - hindawi.com Following the encouraging report of the Edmonton group, there was a rejuvenation
of the islet transplantation field. After that, more pessimistic views spread
when long-term results of the clinical outcome were published. A ... Related articles - Cached - All 2 versions
