K Ichinose, E Kawasaki, K Eguchi - Am J Nephrol, 2007 - content.karger.com Type 1 diabetes mellitus is an autoimmune disease characterized by progressive
destruction of pancreatic beta cells by genetic and environmental factors which
leads to an absolute dependence of insulin for survival and maintenance of ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org MD McKenzie, EM Carrington, T Kaufmann, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Development and function of islets were not affected by loss of Bid,
and Bid-deficient islets were as susceptible as wild-type islets to cytotoxic
stimuli that cause apoptosis via the mitochondrial pathway. In contrast, ... Cited by 12 - Related articles - BL Direct - All 3 versions
MP Morran, GS Omenn, M Pietropaolo - Mt Sinai J Med, 2008 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 7 - Related articles - All 3 versions
YH Van, WH Lee, S Ortiz, MH Lee, HJ Qin, CP … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Our data demonstrated that ATRA treatment inhibited diabetes in NOD
mice with established insulitis. In addition, it suppressed interferon
(IFN)-γ–producing CD4 + and CD8 + T effector (Teff) cells and expanded T ... Cited by 4 - Related articles - All 3 versions
M Pietropaolo, JM Surhigh, PW Nelson, GS … - Diabetes, 2008 - Am Diabetes Assoc For nonimmunologists, a daunting and rapidly evolving immunologic vocabulary,
our incomplete understanding of both normal and abnormal immune function, and
multiple interrelated complex immune cellular pathways can be a barrier to ... Cited by 4 - Related articles - All 9 versions
PD Campbell, E Estella, NL Dudek, G Jhala, … - Human Immunology, 2008 - Elsevier Cytotoxic T lymphocytes (CTL) are believed to play an essential role in β-cell
destruction leading to development of type 1 diabetes and allogeneic islet graft
failure. We aimed to identify the mechanisms used by CTL to kill human β ... Cited by 2 - Related articles - All 2 versions
HE Thomas, MD McKenzie, E Angstetra, PD … - Apoptosis - Springer Abstract Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes
as well as loss of islets after trans- plantation. In type 1 diabetes, beta
cells are destroyed by immunological mechanisms. In type 2 diabetes ... Cited by 2 - Related articles - All 2 versions
G Szabadkai, MR Duchen - Apoptosis - Springer Abstract Mitochondrial dysfunction plays a role in the pathogenesis of a wide
range of diseases that involve dis- ordered cellular fuel metabolism and
survival/death path- ways, including neurodegenerative diseases, cancer and ... Related articles - All 2 versions
HE Thomas, JA Trapani, TWH Kay - Cell Death & Differentiation, 2009 - nature.com Type 1 diabetes results from autoimmune destruction of pancreatic -cells by CD8
+ T cells. The requirement for CD8 + T cells implicates perforin and granzymes
as effectors of tissue destruction. Diabetogenic cytotoxic T cells kill ...
WA Boivin, DM Cooper, PR Hiebert, DJ … - Laboratory Investigation, 2009 - nature.com The cytotoxic granzyme B (GrB)/perforin pathway has been traditionally viewed as
a primary mechanism that is used by cytotoxic lymphocytes to eliminate
allogeneic, virally infected and/or transformed cells. Although originally ... Cited by 1 - Related articles - All 2 versions
