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Scholar Results 1 - 10 of about 107 citing Lee: Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial.... (0.12 sec) 

Berberine stimulates glucose transport through a mechanism distinct from insulin


L Zhou, Y Yang, X Wang, S Liu, W Shang, G Yuan, F Li, … - Metabolism, 2007 - Elsevier
Berberine exerts a hypoglycemic effect, but the mechanism remains unknown. In the present
study, the effect of berberine on glucose uptake was characterized in 3T3-L1 adipocytes. It was
revealed that berberine stimulated glucose uptake in 3T3-L1 adipocytes in a dose- and ...
Cited by 27 - Related articles - All 11 versions

Berberine improves glucose metabolism through induction of glycolysis

- physiology.org
J Yin, Z Gao, D Liu, Z Liu, J Ye - American Journal of Physiology- …, 2008 - Am Physiological Soc
Berberine, a botanical alkaloid used to control blood glucose in type 2 diabetes in China, has
recently been reported to activate AMPK. However, it is not clear how AMPK is activated by
berberine. In this study, activity and action mechanism of berberine were investigated in ...
Cited by 26 - Related articles - BL Direct - All 4 versions

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit …


N Turner, JY Li, A Gosby, SWC To, Z Cheng, H Miyoshi, … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—We have made the following novel observations: 1) BBR dose-dependently inhibited
respiration in L6 myotubes and muscle mitochondria, through a specific effect on respiratory
complex I, similar to that observed with metformin and rosiglitazone; 2) activation of AMPK ...
Cited by 24 - Related articles - BL Direct - All 3 versions

IRS1-independent defects define major nodes of insulin resistance

- nih.gov
KL Hoehn, C Hohnen-Behrens, A Cederberg, LE Wu, N … - Cell metabolism, 2008 - Elsevier
Insulin resistance is a common disorder caused by a wide variety of physiological insults, some
of which include poor diet, inflammation, anti-inflammatory steroids, hyperinsulinemia, and
dyslipidemia. The common link between these diverse insults and insulin resistance is ...
Cited by 22 - Related articles - All 5 versions

Microbial production of plant benzylisoquinoline alkaloids


H Minami, JS Kim, N Ikezawa, T … - Proceedings of the …, 2008 - National Acad Sciences
Benzylisoquinoline alkaloids, such as the analgesic compounds morphine and codeine, and
the antibacterial agents berberine, palmatine, and magnoflorine, are synthesized from tyrosine
in the Papaveraceae, Berberidaceae, Ranunculaceae, Magnoliaceae, and many other ...
Cited by 20 - Related articles - BL Direct - All 8 versions

Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid …


Y Zhang, X Li, D Zou, W Liu, J Yang, N Zhu, L … - Journal of Clinical …, 2008 - Endocrine Soc
Results: In the berberine group, fasting and postload plasma glucose decreased from 7.0 ± 0.8
to 5.6 ± 0.9 and from 12.0 ± 2.7 to 8.9 ± 2.8 mM/liter, HbA1c from 7.5 ± 1.0% to 6.6 ± 0.7%, triglyceride
from 2.51 ± 2.04 to 1.61 ± 1.10 mM/liter, total cholesterol from 5.31 ± 0.98 to 4.35 ± 0.96 ...
Cited by 20 - Related articles - All 11 versions

Efficacy of berberine in patients with type 2 diabetes


J Yin, H Xing, J Ye - Metabolism: clinical and experimental, 2008 - pubmedcentral.nih.gov
Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. This
pilot study was to determine the efficacy and safety of berberine in the treatment of type 2 diabetic
patients. In study A, 36 adults with newly diagnosed type 2 diabetes were randomly ...
Cited by 14 - Related articles - All 12 versions

Antidiabetic activities of triterpenoids isolated from bitter melon associated with …

- cell.com
MJ Tan, JM Ye, N Turner, C Hohnen-Behrens, CQ Ke, … - Chemistry & biology, 2008 - Elsevier
Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established
karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These
compounds and their aglycones exhibited a number of biologic effects beneficial to ...
Cited by 15 - Related articles - All 6 versions

Traditional Chinese medicine in treatment of metabolic syndrome


J Yin, H Zhang, J Ye - … metabolic & immune disorders drug targets, 2008 - pubmedcentral.nih.gov
Cited by 12 - Related articles - BL Direct - All 3 versions

AMP-activated protein kinase: structure and regulation


P Sanz - Current Protein and Peptide Science, 2008 - ingentaconnect.com
Abstract: Mammalian AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase
that acts as a sensor of cellular energy status. It is activated by a large variety of cellular stresses
that increase cellular AMP and decrease ATP levels and also by physiological stimuli, ...
Cited by 12 - Related articles - All 3 versions


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