S Schenk, M Saberi, JM Olefsky - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor
in the etiology of a number of diseases, including type 2 diabetes. In this
review, we discuss potential mechanisms by which brief nutrient excess and ... Cited by 47 - Related articles - All 12 versions
EW Kraegen, GJ Cooney - Current Opinion in Lipidology, 2008 - journals.lww.com Introduction The hypothesis that insulin resistance is related to tri- glyceride
accumulation in muscle and liver dates back to studies of 15–20 years ago
showing that triglyceride accumulates in muscle of high fat-fed rats, ... Cited by 25 - Related articles - BL Direct - All 2 versions
- ►physiology.org C Moro, S Bajpeyi, SR Smith - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Increased intramyocellular triglyceride (IMTG) content is found in both
insulin-sensitive endurance-trained subjects and insulin-resistant obese/type 2
diabetic subjects. A high turnover rate of the IMTG pool in athletes is ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►physiology.org GP Holloway, A Thrush, GJF Heigenhauser, … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc A reduction in fatty acid oxidation has been associated with lipid accumulation
and insulin resistance in the skeletal muscle of obese individuals. We examined
whether this decrease in fatty acid oxidation was attributable to a ... Cited by 23 - Related articles - BL Direct - All 7 versions
M Straczkowski, I Kowalska, M Baranowski, A … - Diabetologia, 2007 - Springer Page 1. ARTICLE Increased skeletal muscle ceramide level in men at risk of developing
type 2 diabetes M. Straczkowski & I. Kowalska & M. Baranowski & ... Cited by 19 - Related articles - BL Direct - All 3 versions
ML Paddock, SE Wiley, HL Axelrod, AE Cohen … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Iron–sulfur (Fe–S) proteins are key players in vital processes involving
energy homeostasis and metabolism from the simplest to most complex organisms.
We report a 1.5 Å x-ray crystal structure of the first identified outer ... Cited by 19 - Related articles - BL Direct - All 12 versions
K Højlund, D Glintborg, NR Andersen, JB Birk … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Impaired insulin-mediated total (R d ) oxidative and nonoxidative
glucose disposal (NOGD) was paralleled by reduced insulin-stimulated Akt
phosphorylation at Ser473 and Thr308 and AS160 phosphorylation in muscle of ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►bentham.org [PDF] GR Steinberg, B Jorgensen… - Mini reviews in medicinal chemistry, 2007 - ingentaconnect.com Gregory R. Steinberg * and Sebastian Beck Jørgensen St. Vincent's Institute of
Medical Research and Department of Medicine, University of Melbourne, Melbourne,
Australia Abstract: Over the past decade, an epidemic of obesity has ... Cited by 17 - Related articles - BL Direct - All 6 versions
NL Dzamko, JD Schertzer, J Ryall, R Steel, … - The Journal of Physiology, 2008 - Physiological Soc The activation of AMP-activated protein kinase (AMPK) and
phosphorylation/inhibition of acetyl-CoA carboxylase 2 (ACC2) is believed to be
the principal pathway regulating fatty acid oxidation. However, during ... Cited by 13 - Related articles - All 5 versions
N Turner, LK Heilbronn - Trends in Endocrinology & Metabolism, 2008 - Elsevier Insulin resistance is a key defect associated with obesity and type-2 diabetes.
The precise factors that lead to insulin resistance have not been elucidated
fully, but there is a strong association between insulin resistance and ... Cited by 13 - Related articles - All 5 versions
