PC Butler, JJ Meier, AE Butler, A Bhushan - Nature clinical practice. Endocrinology & metabolism, 2007 - ncbi.nlm.nih.gov Replication of beta cells is an important source of beta-cell expansion in early
childhood. The recent linkage of type 2 diabetes with several transcription
factors involved in cell cycle regulation implies that growth of the ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet
amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, ... Cited by 28 - Related articles - BL Direct - All 4 versions
BA Menge, A Tannapfel, O Belyaev, R Drescher … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Protocol 1: fasting glucose concentrations increased significantly
after the 50% pancreatectomy (P = 0.01), but the fractional β-cell area of the
pancreas remained unchanged (P = 0.11). β-Cell proliferation, the overall ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►pubget.com [PDF] AE Butler, R Galasso, JJ Meier, R Basu, RA … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Type 1 diabetes is characterised by a deficit in beta
cell mass thought to be due to immune- mediated increased beta cell apoptosis.
Beta cell turnover has not been examined in the context of new-onset type 1 ... Cited by 20 - Related articles - BL Direct - All 3 versions
R Lupi, S Del Prato - Diabetes and Metabolism, 2008 - Elsevier Type 2 diabetes, the most common form of diabetes in humans, is characterized by
impaired insulin secretion paralleled by a progressive decline in β-cell
function and chronic insulin resistance. Several authors have showed that ... Cited by 19 - Related articles - All 2 versions
- ►cell.com EJP de Koning, S Bonner-Weir, TJ Rabelink - Trends in Pharmacological Sciences, 2008 - Elsevier Type 2 diabetes is characterized by progressive β-cell dysfunction and a
reduction in β-cell mass. Pancreatic islets are a target for adverse effectors
such as high concentrations of glucose, pro-inflammatory cytokines and ... Cited by 11 - Related articles - All 4 versions
- ►nih.gov - Free from Publisher AF Kumar, RWG Gruessner, ER Seaquist - Diabetes Care, 2008 - Am Diabetes Assoc OBJECTIVE—Hemipancreatectomy (HPx) for the purpose of organ donation has been
associated with a 25% risk of developing abnormal glucose tolerance or diabetes
in the year after surgery. Since 1997, the University of Minnesota has ... Cited by 10 - Related articles - All 5 versions
AV Matveyenko, PC Butler - Diabetes Obes Metab, 2008 - interscience.wiley.com Regulation of blood glucose concentrations requires an adequate number of
β-cells that respond appropriately to blood glucose levels. β-Cell mass cannot
yet be measured in humans in vivo, necessitating autopsy studies, although ... Cited by 8 - Related articles - All 2 versions
V Sordi, F Bertuzzi, L Piemonti - Regen. Med., 2008 - Future Medicine In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing
β-cells are a major cause of defective control of blood glucose and its
complications. Restoration of damaged β-cells by endocrine pancreas ... Cited by 5 - Related articles - BL Direct - All 4 versions
- ►physiology.org AV Matveyenko, JD Veldhuis, PC Butler - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc In health insulin is secreted in discrete insulin secretory bursts from
pancreatic β-cells, collectively referred to as β-cell mass. We sought to
establish the relationship between β-cell mass, insulin secretory-burst ... Cited by 3 - Related articles - All 4 versions
