- ►diabetesjournals.org HI Callewaert, CA Gysemans, L Ladrière, W D … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Exposure of β-cells to inflammatory cytokines leads to apoptotic
cell death through the activation of gene networks under the control of specific
transcription factors, such as interferon-γ–induced signal transducer ... Cited by 13 - Related articles - BL Direct - All 6 versions
A Riboulet-Chavey, F Diraison, LK Siew, FS … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— Clonal MIN6 β-cells or CD1 mouse pancreatic
islets were infected with recombinant adenoviruses encoding enhanced green
fluorescent protein (eGFP/null), constitutively active AMPK (AMPK-CA), or ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MD McKenzie, EM Carrington, T Kaufmann, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Development and function of islets were not affected by loss of Bid,
and Bid-deficient islets were as susceptible as wild-type islets to cytotoxic
stimuli that cause apoptosis via the mitochondrial pathway. In contrast, ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►nih.gov KL Graham, N Sanders, Y Tan, J Allison, … - Journal of Virology, 2008 - Am Soc Microbiol Infection modulates type 1 diabetes, a common autoimmune disease characterized
by the destruction of insulin-producing islet β cells in the pancreas.
Childhood rotavirus infections have been associated with exacerbations in ... Cited by 6 - Related articles - All 8 versions
NJ Hill, M Hultcrantz, N Sarvetnick, M … - European journal of immunology, 2007 - interscience.wiley.com Central and peripheral tolerance mechanisms were for a long time the only
regulatory circuits known in autoimmunity. It is now becoming clear that the
target tissue itself may have the capacity to control its own destiny. Here ... Cited by 6 - Related articles - BL Direct - All 4 versions
NJ Hill, A Stotland, M Solomon, P Secrest, E … - Biology Direct, 2007 - biology-direct.com Type 1 diabetes occurs when self-reactive T lymphocytes destroy the
insulin-producing islet β cells of the pancreas. The defects causing this
disease have often been assumed to occur exclusively in the immune system. ... Cited by 4 - Related articles - Cached - All 9 versions
MLB Jacobsen, SG Rønn, C Bruun, CM Larsen, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Chemokines recruit activated immune cells to sites of
inflammation and are important mediators of insulitis. Activation of the
pro-apoptotic receptor Fas leads to apoptosis-mediated death of the Fas- ... Cited by 3 - Related articles - All 2 versions
JP Mordes, L Cort, E Norowski, J Leif, JM … - Mammalian Genome, 2009 - Springer Abstract Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated
with autoimmune diabetes. Its effects have been well-documented in BB-derived
rats in which diabetes is either induced by immunologic perturba- tion or ... Cited by 4 - Related articles - All 2 versions
PD Campbell, E Estella, NL Dudek, G Jhala, … - Human Immunology, 2008 - Elsevier Cytotoxic T lymphocytes (CTL) are believed to play an essential role in β-cell
destruction leading to development of type 1 diabetes and allogeneic islet graft
failure. We aimed to identify the mechanisms used by CTL to kill human β ... Cited by 1 - Related articles - All 2 versions
