G Parnaud, D Bosco, T Berney, F Pattou, J … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis The aim of the study was to determine whether purified
beta cells can replicate in vitro and whether this is enhanced by extracellular
matrix (ECM) and growth factors. Methods Human beta cells were purified by ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org L Shu, NS Sauter, FT Schulthess, AV … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—To investigate the effects of TCFL7L2 depletion,
isolated islets were exposed to TCF7L2 small interfering RNA (siRNA) versus
scrambled siRNA, and β-cell survival and function were examined. For ... Cited by 37 - Related articles - BL Direct - All 4 versions
BA Menge, A Tannapfel, O Belyaev, R Drescher … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Protocol 1: fasting glucose concentrations increased significantly
after the 50% pancreatectomy (P = 0.01), but the fractional β-cell area of the
pancreas remained unchanged (P = 0.11). β-Cell proliferation, the overall ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N … - Endocrine Reviews, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro
discovery in 1984, evolving via descriptive and phenomenological studies to
detailed mapping of the signalling pathways, gene- and protein expression ... Cited by 20 - Related articles - BL Direct - All 6 versions
- Free from Publisher E Szoke, MZ Shrayyef, S Messing, HJ Woerle, … - Diabetes Care, 2008 - Am Diabetes Assoc RESULTS—As expected, both phases of insulin release and insulin sensitivity
were reduced in individuals with IGT (all P < 0.01). Insulin sensitivity was not
independently correlated with age in either group. In people with NGT, the ... Cited by 13 - Related articles - BL Direct - All 4 versions
F Levine, P Itkin-Ansari - Journal of Molecular Medicine, 2008 - Springer Abstract Both type I and type II diabetes are characterized by β-cell loss and
dysfunction. Therefore, a major goal of diabetes therapy is to promote the
formation of new β-cells, either in vitro for transplantation or in vivo, ... Cited by 8 - Related articles - All 3 versions
K Maedler - Diabetes Obesity and Metabolism, 2008 - interscience.wiley.com The healthy β-cell has an enormous capacity to adapt to conditions of higher
insulin demand (eg in obesity, pregnancy, cortisol excess) to maintain
normoglycaemia with an increase in its functional β-cell mass. This ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Liadis, L Salmena, E Kwan, P Tajmir, SA … - Diabetes, 2007 - Am Diabetes Assoc Inadequate pancreatic β-cell mass resulting from excessive β-cell apoptosis is
a key defect in type 1 and type 2 diabetes. Caspases are the major molecules
involved in apoptosis; however, in vivo roles of specific caspases in ... Cited by 5 - Related articles - BL Direct - All 4 versions
- ►physiology.org S Chen, S Turner, E Tsang, J Stark, H Turner, … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc We describe a sensitive technique for measuring long-term islet cell
proliferation rates in vivo in rats. Pancreatic islets were isolated and the
incorporation of deuterium ( 2 H) from heavy water ( 2 H 2 O) into the ... Cited by 4 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org T Brun, KHH He, R Lupi, B Boehm, A … - Human Molecular Genetics, 2008 - Oxford Univ Press We previously demonstrated that the transcription factor Pax4 is important for
β-cell replication and survival in rat islets. Herein, we investigate Pax4
expression in islets of non-diabetic and diabetic donors, its regulation by ... Cited by 4 - Related articles - BL Direct - All 4 versions
