- ►aspetjournals.org Y Fujimori, K Katsuno, I Nakashima, Y … - Journal of Pharmacology and Experimental …, 2008 - ASPET The low-affinity sodium glucose cotransporter (SGLT2) plays an important role in
renal glucose reabsorption and is a remarkable transporter as a molecular target
for the treatment of diabetes. We have discovered remogliflozin etabonate, ... Cited by 10 - Related articles - All 4 versions
- ►physiology.org VA Payne, C Arden, AJ Lange, L Agius - … Journal of Physiology- Regulatory, Integrative and …, 2007 - Am Physiological Soc The insulin-resistant Zucker fa/fa rat has elevated hepatic glycolysis and
activities of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2
(PFK2). The latter catalyzes the formation and degradation of fructose-2,6- ... Cited by 6 - Related articles - BL Direct - All 5 versions
S Mittra, VS Bansal, PK Bhatnagar - Drug discovery today, 2008 - Elsevier Insulin resistance, the essential component of metabolic syndrome, has
traditionally been defined from a glucocentric viewpoint, with glucotoxicity
playing a lead role. However, as overabundant circulating fatty acids are ... Cited by 5 - Related articles - All 3 versions
- ►physiology.org JS Shin, TP Torres, REL Catlin, EP Donahue, … - … Journal of Physiology- Regulatory, Integrative and …, 2007 - Am Physiological Soc Effect of stimulation of glucokinase (GK) export from the nucleus by small
amounts of sorbitol on hepatic glucose flux in response to elevated plasma
glucose was examined in 6-h fasted Zucker diabetic fatty rats at 10 wk of ... Cited by 4 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] S Satapati, TT He, T Inagaki, M Potthoff, ME … - Diabetes, 2008 - Am Diabetes Assoc Page 1. NMR Analysis of Hepatic Fat Oxidation Partial resistance to PPARα
agonists in Zucker diabetic fatty (ZDF) rats is associated ... Cited by 3 - Related articles - All 3 versions
- ►aspetjournals.org [PDF] Y Fujimori, K Katsuno, I Nakashima, Y … - Journal of Pharmacology and Experimental …, 2008 - ASPET Page 1. JPET#140210 1 TITLE PAGE Remogliflozin etabonate, in a Novel Category
of Selective Low-Affinity / High-Capacity Sodium Glucose ... Cited by 3 - Related articles
- ►diabetesjournals.org S Satapati, TT He, T Inagaki, M Potthoff, ME … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Hepatic mitochondrial fat oxidation in the diabetic liver was impaired
twofold secondary to decreased ketogenesis, but tricarboxylic acid (TCA) cycle
activity and pyruvate carboxylase flux were normal in newly diabetic rats ... Cited by 2 - Related articles - All 6 versions
Y Brunner, D Schvartz, F Priego-Capote, Y … - Journal of Proteomics, 2009 - Elsevier Chronic hyperglycaemia is one of the main characteristics of a diabetic state.
This is also the first cause of diabetic complications. However, it is now
generally accepted that glucotoxicity also participates in the worsening of ... Cited by 1 - Related articles - All 2 versions
F Francini, MC Castro, JJ Gagliardino, ML … - Canadian Journal of Physiology and Pharmacology, 2009 - ingentaconnect.com Abstract: We evaluated the relative role of different regulatory mechanisms,
particularly 6-phosphofructo-2-kinase/fruc- tose-2,6-biphosphatase
(PFK2/FBPase-2), in liver glucokinase (GK) activity in intact animals with ... Related articles - All 2 versions
