- ►endojournals.org WL Holland, SA Summers - Endocrine Reviews, 2008 - Endocrine Soc Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and cardiovascular
disease. Sphingolipids such as ceramide and glucosylceramides, while being a relatively minor
component of the lipid milieu in most tissues, may be among the most pathogenic lipids in ... Cited by 30 - Related articles - All 7 versions
KH Pietiläinen, M Sysi-Aho, A Rissanen, T … - PLoS One, 2007 - pubmedcentral.nih.gov Both genetic and environmental factors are involved in the etiology of obesity and the associated
lipid disturbances. We determined whether acquired obesity is associated with changes in global
serum lipid profiles independent of genetic factors in young adult monozygotic (MZ) twins. ... Cited by 26 - Related articles - All 6 versions
- ►fasebj.org BS Paugh, SW Paugh, L Bryan, D Kapitonov, KM … - The FASEB Journal, 2008 - FASEB Patients with gliomas expressing high levels of epidermal growth factor receptor (EGFR) and
plasminogen activator inhibitor-1 (PAI-1) have a shorter overall survival prognosis.
Moreover, EGF enhances PAI-1 expression in glioma cells. Although multiple known ... Cited by 16 - Related articles - BL Direct - All 5 versions
C Shah, G Yang, I Lee, J Bielawski, YA Hannun, F … - Journal of Biological …, 2008 - ASBMB Obesity increases the risk for metabolic and cardiovascular disease, and adipose tissue plays
a central role in this process. Ceramide, the key intermediate of sphingolipid metabolism, also
contributes to obesity-related disorders. We show that a high fat diet increased ceramide ... Cited by 9 - Related articles - All 4 versions
- ►diabetesjournals.org JM Haus, SR Kashyap, T Kasumov, R Zhang, KR Kelly, … - Diabetes, 2009 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We analyzed fasting plasma ceramide subspecies by
quantitative tandem mass spectrometry in 13 obese type 2 diabetic patients and 14 lean healthy
control subjects. Results were related to insulin sensitivity measured with the ... Cited by 11 - Related articles - All 4 versions
U Schwab, T Seppänen-Laakso, L Yetukuri, J Ågren, … - PLoS ONE, 2008 - pubmedcentral.nih.gov Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group
were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight
decreased in the weight reduction group by 7.8±2.9% (p<0.01). Most of the serum ... Cited by 8 - Related articles - All 8 versions
A Rudich, H Kanety, N Bashan - Trends in Endocrinology & Metabolism, 2007 - Elsevier Obesity has been proposed to inflict a variety of stresses on adipose tissue, including
inflammatory, metabolic, oxidative and endoplasmic reticulum stress. Through the activation
of 'stress-sensing pathways', metabolic and endocrine alterations are produced, which ... Cited by 6 - Related articles - All 4 versions
- ►uva.nl [PDF] M Langeveld, JMFG Aerts - Progress in Lipid Research, 2009 - Elsevier Obesity is associated with an increased risk for insulin resistance, a state characterized by impaired
responsiveness of liver, muscle and adipose tissue to insulin. One class of lipids involved in
the development of insulin resistance are the (glyco)sphingolipids. Ceramide, the most ... Cited by 5 - Related articles - All 3 versions
- ►endojournals.org N Arai, H Masuzaki, T Tanaka, T Ishii, S Yasue, N … - Endocrinology, 2007 - Endocrine Soc Increased activity of intracellular glucocorticoid reactivating enzyme, 11β-hydroxysteroid dehydrogenase
type 1 (11β-HSD1) in obese adipose tissue contributes to adipose dysfunction. As recent studies
have highlighted a potential role of preadipocytes in adipose dysfunction, we tested the ... Cited by 2 - Related articles - BL Direct - All 2 versions
F Samad - Future Lipidol., 2007 - Future Medicine Insulin resistance, Type 2 diabetes and accelerated atherosclerosis are common health complications
associated with obesity, and increasing evidence suggest that a complex proinflammatory state
together with increased lipid accumulation in extra adipose tissues, such as the liver and ... Cited by 2 - Related articles - BL Direct - All 3 versions
