TP Di Lorenzo, M Peakman, BO … - Clinical and Experimental …, 2007 - pubmedcentral.nih.gov T cell epitopes represent the molecular code words through which the adaptive immune system
communicates. In the context of a T cell-mediated autoimmune disease such as type 1
diabetes, CD4 and CD8 T cell recognition of islet autoantigenic epitopes is a key step in ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli, G … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells, detection
of these rare lymphocytes remains largely elusive. Suitable T-cell assays are highly needed,
since they could offer preclinical diagnoses and immune surrogate end points for clinical ... Cited by 31 - Related articles - BL Direct - All 6 versions
M Knip, H Siljander - Autoimmunity Reviews, 2008 - Elsevier Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical
prodromal period characterized by selective loss of insulin-producing β-cells in the pancreatic
islets in genetically susceptible subjects. Autoreactive T cells, both CD4 and CD8 cells, ... Cited by 24 - Related articles - All 2 versions
- ►jimmunol.org P Monti, M Scirpoli, A Rigamonti, A Mayr, A … - The Journal of …, 2007 - Am Assoc Immnol Identifying cell autoantigen-reactive T cells that are involved in the pathogenesis of type 1 diabetes
has been troublesome for many laboratories. Disease-relevant autoreactive T cells should be
in vivo Ag experienced. The aim of this study was to test this hypothesis and then use this ... Cited by 17 - Related articles - All 4 versions
- ►diabetesjournals.org E Martinuzzi, G Novelli, M Scotto, P Blancou, JM Bach, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—CD8 + T-cell reactivities were less frequent at follow-up, as 28.6% of responses
tested positive at type 1 diabetes diagnosis vs. 13.2% after a median of 11 months (P =
0.003). While GAD and IA-2 autoantibody (aAb) titers were unchanged in 75% of cases, ... Cited by 12 - Related articles - BL Direct - All 9 versions
B Banwell, A Bar-Or, R Cheung, J Kennedy, … - Annals of …, 2008 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 9 - Related articles - BL Direct - All 2 versions
S Glisic-Milosavljevic, T Wang, M Koppen, … - Clinical and …, 2007 - pubmedcentral.nih.gov Because type 1 diabetes (T1D) is a chronic, autoimmune, T cell-mediated disease, interventions
affecting T cells are expected to modulate the immune cascade and lead to disease
remission. We propose that increased CD4 + CD25 +high T cell apoptosis, a trait we ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org A Goel, H Chiu, J Felton, JP Palmer, B Brooks-Worrell - Diabetes, 2007 - Am Diabetes Assoc Latent autoimmune diabetes in adults or type 1.5 diabetes is considered to be a T-cell–mediated
autoimmune disease. However, identification of patients is based commonly on autoantibody
(Ab) detection. To determine whether measuring T-cell reactivity to islet proteins ... Cited by 5 - Related articles - BL Direct - All 6 versions
R Mallone, P van Endert - Current Diabetes Reports, 2008 - Springer T lymphocytes' crucial role in the autoimmune process leading to insulin-dependent type 1 diabetes
is now universally recognized. Research focuses on identifying pathogenic and nonpathogenic
T cells, understanding how they are primed and expanded, characterizing their antigen ... Cited by 3 - Related articles - BL Direct - All 4 versions
H Tsui, Y Chan, L Tang, S Winer, RK Cheung, G … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— pSC cultures did not express major histocompatibility complex (MHC) class II and
were lysed by ex vivo CTLs from diabetic NOD mice. In vivo, restoration of MHC class I in
GFAP-β2m transgenics significantly accelerated adoptively transferred diabetes. Target ... Cited by 4 - Related articles - BL Direct - All 4 versions
