- ►endojournals.org JT Smith, CM Clay, A Caraty, IJ Clarke - Endocrinology, 2007 - Endocrine Soc The KiSS-1 gene encodes a family of peptides called kisspeptins, which are
endogenous ligands for the G protein-coupled receptor GPR54. Kisspeptin function
appears to be critical for GnRH secretion and the initiation of puberty. To ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►ciberobn.es [PDF] J Roa, E Aguilar, C Dieguez, L Pinilla, M … - Frontiers in Neuroendocrinology, 2008 - Elsevier Identification, in late 2003, of inactivating mutations of the G protein-coupled
receptor GPR54 as causative factor for absence of puberty and hypogonadotropic
hypogonadism in humans and mice was a major breakthrough in modern ... Cited by 50 - Related articles - All 8 versions
- ►washington.edu [PDF] SM Popa, DK Clifton, RA Steiner, 2008 - Annual Reviews Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the
circuitry that regulates GnRH neurons is fundamental to comprehending the ... Cited by 43 - Related articles - BL Direct - All 6 versions
M Tena-Sempere - Neuroendocrinology, 2006 - content.karger.com Unraveling of the master role of kisspeptins, the products of the KiSS-1 gene,
and their receptor, GPR54, in the control of reproduction has been a major
breakthrough in contemporary neuroendocrinology. Indeed, since the ... Cited by 36 - Related articles - BL Direct - All 6 versions
- ►endojournals.org WS Dhillo, OB Chaudhri, EL Thompson, KG … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Context: Kisspeptin, the endogenous ligand of the G protein-coupled receptor 54,
is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null
mice exhibit reproductive dysfunction, and exogenous kisspeptin potently ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►nursing2008.com RR Kalyani, AS Dobs - Current Opinion in Endocrinology, Diabetes and …, 2007 - journals.lww.com Recent findings: Various definitions of hypogonadism, the metabolic syndrome and
diabetes have been proposed and are used in the literature. Cross-sectional
studies have found that between 20 and 64% of men with diabetes have ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►endojournals.org RM Luque, RD Kineman, M Tena-Sempere - Endocrinology, 2007 - Endocrine Soc It is well established that reproductive function is metabolically gated.
However, the mechanisms whereby energy stores and metabolic cues influence
fertility are yet to be completely deciphered. Recently, the hypothalamic ... Cited by 25 - Related articles - BL Direct - All 7 versions
- ►ciberobn.es [PDF] VM Navarro, JM Castellano, D García- … - Reviews in Endocrine & Metabolic Disorders, 2007 - Springer Abstract Puberty is the end-point of a complex series of developmental events,
defined by the dynamic interaction between genetic factors and environmental
cues, ultimately leading to the attainment of reproductive capacity. The ... Cited by 24 - Related articles - BL Direct - All 8 versions
- ►physiology.org JW Hill, JK Elmquist, CF Elias - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc During periods of metabolic stress, animals must channel energy toward survival
and away from processes such as reproduction. The reproductive axis, therefore,
has the capacity to respond to changing levels of metabolic cues. The ... Cited by 26 - Related articles - BL Direct - All 5 versions
EJ Mead, JJ Maguire, RE Kuc, AP Davenport - British Journal of Pharmacology, 2007 - pubmedcentral.nih.gov Orphan G-protein-coupled receptors that have recently been paired with their
cognate ligand are an often untapped resource for novel drug development. The
KISS1 receptor (previously designated GPR54) has been paired with ... Cited by 21 - Related articles - BL Direct - All 3 versions
