KR Owen, MI McCarthy - Current opinion in genetics & development, 2007 - Elsevier Identification and characterization of genetic variants that either cause or predispose to diabetes
are a major focus of biomedical research. As of early 2007, the molecular basis of most forms
of monogenic diabetes resulting from β-cell dysfunction is known and, in particular, there ... Cited by 36 - Related articles - All 4 versions
JC Florez - Diabetologia, 2008 - Springer Abstract Although type 2 diabetes has been traditionally understood as a metabolic disorder
initiated by insulin resistance, it has recently become apparent that an impairment in insulin secretion
contributes to its mani- festation and may play a prominent role in its early ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] JB McAteer, S Prudente, S Bacci, HN Lyon, JN … - Diabetes, 2007 - Am Diabetes Assoc From the 1 Diabetes Unit and Center for Human Genetic Research, Massachusetts General
Hospital, Boston, Massachusetts; 2 the Program in Medical and Population Genetics, Broad Institute
of Harvard and MIT, Cambridge, Massachusetts; 3 Research Unit of Diabetes and ... Cited by 22 - Related articles - BL Direct - All 3 versions
D Meyre, N Bouatia-Naji, V Vatin, J Veslot, C Samson, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis We assessed the predictive value of ectonu- cleotide
pyrophosphatase/phosphodiesterase 1 gene (ENPP1) SNPs with regard to the risk of developing
obesity and/or type 2 diabetes in a large French general population. Methods We ... Cited by 20 - Related articles - BL Direct - All 3 versions
- ►kuleuven.be [PDF] CC Elbers, NC Onland-Moret, L Franke, AG Niehoff, … - Trends in Endocrinology & …, 2007 - Elsevier Worldwide, the incidence of type 2 diabetes is rising rapidly, mainly because of the increase
in the incidence of obesity, which is an important risk factor for this condition. Both obesity and
type 2 diabetes are complex genetic traits but they also share some nongenetic risk ... Cited by 18 - Related articles - All 7 versions
S Cauchi, H Choquet, R Gutiérrez-Aguilar, F Capel, K … - Obesity, 2008 - nature.com In white European populations, we found that the rs7903146 T allele was more associated with
T2D in 3,547 non-obese individuals (odds ratio (OR) = 1.88 (1.69–2.10)) than in 1,110 class
III obese subjects (OR = 1.24 (1.03–1.50)). No direct effect of the rs7903146 C allele and ... Cited by 18 - Related articles - All 2 versions
S Cauchi, KT Nead, H Choquet, F Horber, N … - BMC Medical …, 2008 - biomedcentral.com Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L
[odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR
= 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 × 10 -23 ), and ... Cited by 15 - Related articles - Cached - All 9 versions
N Abate, M Chandalia, R Di Paola, DW Foster, … - Nature Reviews …, 2006 - nature.com Insulin resistance is pathogenic for type 2 diabetes and cardiovascular disease. Several inhibitors
of insulin signaling have a role in human insulin resistance. The transmembrane glycoprotein
ectonucleotide pyrophosphatase phosphodiesterase 1 (E-NPP1; also known as plasma ... Cited by 11 - Related articles - BL Direct - All 3 versions
S Bacci, S De Cosmo, S Prudente, V … - Current Opinion in Clinical …, 2007 - journals.lww.com Purpose of review: Insulin resistance plays a significant role in both morbidity and mortality of
the general population. Understanding the molecular mechanisms of insulin resistance would
help the identification of at-risk individuals in the presymptomatic stage, and the discovery ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►geyseco.info [PDF] JC Florez - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Evidence Synthesis: As many as 17 genetic loci have been convincingly associated with type
2 diabetes; 14 of these were not previously known, and most of them were unsuspected. The
associated polymorphisms are common in populations of European descent but have ... Cited by 12 - Related articles - All 4 versions
