- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
SC Elbein - Current Opinion in Clinical Nutrition & Metabolic Care, 2007 - journals.lww.com Purpose of review Populations of direct African ancestry have much greater genetic diversity
than do other populations. African– American populations exhibit twice the prevalence of type
2 diabetes as compared with their Caucasian counterparts. African–American ... Cited by 14 - Related articles - BL Direct - All 5 versions
SK Das, SC Elbein - Current Diabetes Reports, 2007 - Springer The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of
type 2 diabetes mel- litus to the chromosome 1q21-25 region in at least eight independent
studies. More than 26 candidate genes have already been evaluated, but to date none ... Cited by 14 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org WS Chu, SK Das, H Wang, JC Chan, P Deloukas, P … - Diabetes, 2007 - Am Diabetes Assoc Activating transcription factor 6 (ATF6) is located within the region of linkage to type 2 diabetes
on chromosome 1q21-q23 and is a key activator of the endoplasmic reticulum stress
response. We evaluated 78 single nucleotide polymorphisms (SNPs) spanning >213 kb ... Cited by 8 - Related articles - BL Direct - All 12 versions
SJ Hasstedt, WS Chu, SK Das, H Wang, … - Annals of Human …, 2008 - interscience.wiley.com Type 2 diabetes (T2D) has been linked to chromosome 1q21–24 in multiple samples, including
a Utah family sample. Variants in 13 of the numerous candidate genes in the 1q region were
tested for association with T2D in a Utah case-control sample. The most promising, 19 ... Cited by 4 - Related articles - BL Direct - All 3 versions
MM Sale, L Lu, IJ Spruill, JK Fernandes, KH Lok, J … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Linkage peaks on chromosome 14 at 123–124 cM were detected for type 2 diabetes
(logarithm of odds [LOD] 2.10) and for the subset with later age at type 2 diabetes diagnosis
(maximum LOD 4.05). Two linkage peaks on chromosome 7 were detected at 44–45 cM ... Cited by 2 - Related articles - All 3 versions
CA Bonham, PO Vacratsis - Journal of Biological Chemistry, 2009 - ASBMB YVH1 was one of the first eukaryotic dual specificity phosphatases cloned, and orthologues posses
a unique C-terminal zinc-coordinating domain in addition to a cysteine-based phosphatase
domain. Our recent results revealed that human YVH1 (hYVH1) protects cells from ... Cited by 1 - Related articles - All 3 versions
H Wang, NP Hays, SK Das, RL Craig, WS Chu, … - Journal of Clinical …, 2009 - Endocrine Soc Objective: Linkage to type 2 diabetes (T2D) is well replicated on chromosome 1q21-q23. Within
this region, T2D was associated with common single nucleotide polymorphisms that marked
an extended linkage disequilibrium block, including the liver pyruvate kinase gene ... Related articles - All 3 versions
P Sharda, C Bonham, E Mucaki, Z Butt, P Vacratsis - Biochem. J, 2009 - biochemjusa.org Biochem. J. (2009) 418, 391–401 (Printed in Great Britain) doi:10.1042/BJ20081484 ... The
dual-specificity phosphatase hYVH1 interacts with Hsp70 and ... Priya R. SHARDA, Christopher
A. BONHAM, Eliseos J. MUCAKI, Zareen BUTT and Panayiotis O. VACRATSIS1 ... Related articles - View as HTML - All 5 versions
