- ►daegu.ac.kr [PDF] R Sladek, G Rocheleau, J Rung, C Dina, L … - Nature, 2007 - nature.com Type 2 diabetes mellitus results from the interaction of environmental factors
with a combination of genetic variants, most of which were hitherto unknown. A
systematic search for these variants was recently made possible by the ... Cited by 770 - Related articles - BL Direct - All 14 versions
J Marchini, B Howie, S Myers, G McVean, P … - Nature, 2007 - wiki.case.edu Genome-wide association studies are set to become the method of choice for
uncovering the genetic basis of human diseases. A central challenge in this area
is the development of powerful multipoint methods that can detect causal ... Cited by 283 - Related articles - View as HTML - BL Direct - All 16 versions
- ►umich.edu [PDF] SJ Chanock, T Manolio, M Boehnke, E …, 2007 - deepblue.lib.umich.edu Initial association studies The initial study of any association represents an
important discovery tool. In the near future, it is unlikely that a single study
will unequivo- cally establish a valid genotype–phenotype association and ... Cited by 280 - Related articles - View as HTML - BL Direct - All 5 versions
A Helgason, S Pálsson, G Thorleifsson, SFA … - Nature genetics, 2007 - nature.com We recently described an association between risk of type 2diabetes and variants
in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a
population attributable risk (PAR) of 17%–28% in three populations of ... Cited by 155 - Related articles - BL Direct - All 11 versions
- ►nih.gov V Lyssenko, L Groop - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Genetic variants in the gene encoding for transcription factor-7–like 2
(TCF7L2) have been associated with type 2 diabetes (T2D) and impaired β cell
function, but the mechanisms have remained unknown. We therefore studied ... Cited by 131 - Related articles - BL Direct - All 13 versions
- ►nthu.edu.tw [PDF] S Cauchi, Y El Achhab, H Choquet, C Dina, F … - Journal of Molecular Medicine, 2007 - Springer Page 1. RAPID COMMUNICATION TCF7L2 is reproducibly associated with type
2 diabetes in various ethnic groups: a global meta-analysis ... Cited by 94 - Related articles - BL Direct - All 4 versions
- ►ccmb.res.in [PDF] GR Chandak, CS Janipalli, S Bhaskar, SR … - Diabetologia, 2007 - Springer Abstract Aims and hypothesis India has the greatest number of diabetic subjects
in any one country, but the genetic basis of type 2 diabetes mellitus in India
is poorly understood. Common non-coding variants in the transcription ... Cited by 85 - Related articles - BL Direct - All 5 versions
M Horikoshi, K Hara, C Ito, R Nagai, P … - Diabetologia, 2007 - Springer Page 1. SHORT COMMUNICATION A genetic variation of the transcription factor 7-like
2 gene is associated with risk of type 2 diabetes in the Japanese population ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►nih.gov E Zeggini, MI McCarthy - Diabetologia, 2007 - Springer Much has been made over the past decade of the potential for genetics to advance
our understanding of the pathogenesis of type 2 diabetes and to 'revolutionise'
management of this condition [1]. Others have argued that these claims are ... Cited by 51 - Related articles - BL Direct - All 6 versions
- ►nih.gov RJF Loos, PW Franks, RW Francis, I Barroso, … - Diabetes, 2007 - Am Diabetes Assoc Rapidly accumulating evidence shows that common T-cell transcription factor
(TCF)7L2 polymorphisms confer risk of type 2 diabetes through unknown
mechanisms. We examined the association between four TCF7L2 single ... Cited by 53 - Related articles - BL Direct - All 8 versions
