GR Hajer, TW van Haeften, FLJ Visseren - European Heart Journal, 2008 - Eur Soc Cardiology The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk
factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes
mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as ... Cited by 34 - Related articles - All 4 versions
GV Rayasam, VK Tulasi, JA Davis, … - Expert opinion on …, 2007 - Informa Pharma Science G-protein-coupled receptors (GPCRs) are key regulators of several physiological functions. Their
roles in cellular signal transduction have made them the target for majority of all currently prescribed
drugs. Additionally, there are many orphan GPCRs that provide potential novel ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Prentki, SR Madiraju - Endocrine reviews, 2008 - Endocrine Soc GL/FFA cycle is referred to as a "futile" cycle because it involves continuous formation and hydrolysis
of GL with the release of heat, at the expense of ATP. However, we present evidence underscoring
the "vital" cellular signaling roles of the GL/FFA cycle for many biological processes. ... Cited by 14 - Related articles - All 5 versions
D Ma, L Lu, NB Boneva, S Warashina, DB … - …, 2008 - interscience.wiley.com Polyunsaturated free fatty acids (PUFAs) are known to play critical roles for the development,
maintenance, and function of the brain. Recently, we reported that G-protein coupled receptor
40 (GPR40), one type of PUFA receptors, is expressed throughout the adult primate ... Cited by 9 - Related articles - BL Direct - All 2 versions
- ►pubget.com [PDF] LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET Identification of G protein-coupled receptors that are activated by free fatty acids has led to considerable
interest in their pharmacology and function because of the wide range of normal physiology and
disease states in which fatty acids have been implicated. Free fatty acid receptor (FFA) 1 ... Cited by 9 - Related articles - All 5 versions
SRM Madiraju, V Poitout - Endocrinology, 2007 - pubmedcentral.nih.gov Type 2 diabetes mellitus is an increasingly prevalent disease throughout the world, with dramatic
consequences in terms of individual well-being, public health, and economy. It is due to a combination
of defective insulin secretion from the pancreatic β-cell and impaired sensitivity of the ... Cited by 8 - Related articles - BL Direct - All 3 versions
- ►cell.com CJ Nolan, M Prentki - Trends in Endocrinology & Metabolism, 2008 - Elsevier The pancreatic β-cell senses blood nutrient levels and is modulated by neurohormonal signals
so that it secretes insulin according to the need of the organism. Nutrient sensing involves marked
metabolic activation, resulting in the production of coupling signals that promote insulin ... Cited by 7 - Related articles - All 8 versions
S Salinari, A Bertuzzi, A Iaconelli, M Manco, G … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis We have previously demonstrated that type 2 diabetes resolves after
bariatric surgery. To study the role of NEFA in the prompt normalisation of beta cell glucose
sensitivity, insulin secretion and beta cell glucose and lipid metabolism were investigated ... Cited by 7 - Related articles - BL Direct - All 2 versions
G Swaminath - Arch Pharm, 2008 - 万方数据资源系统 G-protein-coupled receptors (GPCRs) respond to various physiological ligands such as
photons, ions, and small molecules that include amines, fatty acids, and amino acids to
peptides, proteins and steroids. Therefore, this family of proteins represents an attractive ... Cited by 6 - Related articles - All 2 versions
