- ►physiology.org PL McClean, N Irwin, RS Cassidy, JJ Holst … - American Journal of …, 2007 - Am Physiological Soc The gut hormone gastric inhibitory polypeptide (GIP) plays a key role in glucose homeostasis
and lipid metabolism. This study investigated the effects of administration of a stable and specific
GIP receptor antagonist, (Pro 3 )GIP, in mice previously fed a high-fat diet for 160 days to ... Cited by 27 - Related articles - BL Direct - All 3 versions
- ►qub.ac.uk [PDF] BD Green, PR Flatt - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic
polypeptide (GIP) are physiological gut peptides with insulin-releasing and extrapancreatic glucoregulatory
actions. Incretin analogues/mimetics activate GLP-1 or GIP receptors whilst avoiding ... Cited by 29 - Related articles - All 17 versions
VA Gault, PL McClean, RS Cassidy, N Irwin, PR Flatt - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Gastric inhibitory polypeptide (GIP) re- ceptor antagonism with (Pro
3 )GIP improves glucose toler- ance and ameliorates insulin resistance and abnormalities of
islet structure/function in ob/ob mice. This study examined the ability of (Pro 3 )GIP to ... Cited by 16 - Related articles - BL Direct - All 4 versions
S Edfalk, P Steneberg, H Edlund - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor Gpr40 is expressed in β-cells where it contributes
to free fatty acid (FFA) enhancement of glucose-stimulated insulin secretion (1–4). However,
other sites of Gpr40 expression, including the intestine, have been suggested. The ... Cited by 16 - Related articles - All 4 versions
PR Flatt - Diabetes & Vascular Disease Research, 2007 - dvr.sagepub.com Abstract R oux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to
the general inabil- ity of lifestyle change and existing drug treatments to counter the obesity
epidemic. This common form of bariatric surgery involves bypass of the small intestine ... Cited by 13 - Related articles - BL Direct - All 6 versions
PR Flatt - Diabetic Medicine, 2008 - interscience.wiley.com There is increasing realization that gastric inhibitory polypeptide (GIP) has actions outside of
the pancreas and gastrointestinal tract. Most significant is the presence of functional GIP receptors
on adipocytes and the appreciation that GIP, secreted strongly in response to fat ... Cited by 7 - Related articles - All 3 versions
C Yamada, Y Yamada, K Tsukiyama, K Yamada, S … - … and Biophysical Research …, 2007 - Elsevier Aging is associated with increased fat mass and decreased lean mass, which is strongly associated
with the development of insulin resistance. Gastric inhibitory polypeptide (GIP) is known to promote
efficient storage of ingested nutrients into adipose tissue; we examined aging-associated ... Cited by 5 - Related articles - All 4 versions
PL McClean, N Irwin, K Hunter, VA Gault, … - British journal of …, 2008 - ncbi.nlm.nih.gov BACKGROUND AND PURPOSE: Antagonism of the gastric inhibitory polypeptide (GIP) receptor
with daily injection of proline-3 gastric inhibitory polypeptide ((Pro(3))GIP) can reverse or prevent
many of the metabolic abnormalities associated with diet-induced obesity-diabetes ( ... Cited by 5 - Related articles - All 2 versions
G Muñoz, E Alves, A Fernández, C Óvilo, C … - Animal …, 2007 - interscience.wiley.com Refinement of previous QTL on porcine chromosome 12 for fatty-acid composition and a candidate
gene association analysis were conducted using an Iberian × Landrace cross. The concentrations
of ten fatty acids were assayed in backfat tissue from which four metabolic ratios were ... Cited by 5 - Related articles - BL Direct - All 4 versions
R Naitoh, K Miyawaki, N Harada, W Mizunoya, K … - … and Biophysical Research …, 2008 - Elsevier Gastric inhibitory polypeptide (GIP) is an incretin and directly promotes fat accumulation in
adipocytes. Inhibition of GIP signaling prevents onset of obesity and increases fat oxidation in
peripheral tissues under high-fat diet (HFD), but the mechanism is unknown. In the ... Cited by 2 - Related articles - All 2 versions
