- ►nih.gov CN Lumeng, JL Bodzin, AR Saltiel - Journal of Clinical …, 2007 - Am Soc Clin Investig Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to
insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon
high-fat feeding may differ from those that reside there under normal diet conditions. To ... Cited by 241 - Related articles - BL Direct - All 9 versions
- ►nih.gov C de Luca, JM Olefsky - FEBS letters, 2008 - Elsevier Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin resistance
and the Metabolic syndrome. In this review, we focus on the interconnection between
obesity, inflammation and insulin resistance. Pro-inflammatory cytokines can cause ... Cited by 70 - Related articles - All 11 versions
M Zeyda, D Farmer, J Todoric, O Aszmann, M … - International Journal of …, 2007 - nature.com Like prototypic M2 macrophages, ATMs expressed considerable amounts of mannose
receptor, haemoglobin scavenger receptor CD163 and integrin v 5. The number of cells expressing
these molecules correlated significantly with the donors' body mass indices (BMIs). ... Cited by 57 - Related articles - BL Direct - All 4 versions
- ►holliseden.com [PDF] G Solinas, C Vilcu, JG Neels, GK Bandyopadhyay, JL … - Cell Metabolism, 2007 - Elsevier Obesity-induced insulin resistance is a major factor in the etiology of type 2 diabetes, and Jun
kinases (JNKs) are key negative regulators of insulin sensitivity in the obese state. Activation
of JNKs (mainly JNK1) in insulin target cells results in phosphorylation of insulin receptor ... Cited by 51 - Related articles - All 8 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ... Cited by 47 - Related articles - All 12 versions
- ►ahajournals.org CP Liang, S Han, T Senokuchi, AR Tall - Circulation research, 2007 - Am Heart Assoc The macrophage has emerged as an important player in the pathogenesis of both atherosclerosis
and insulin resistance. Cross-talk between inflammatory macrophages and adipocytes may be
involved in insulin resistance in peripheral tissues. Defective insulin signaling in cells of ... Cited by 43 - Related articles - All 6 versions
M Zeyda, TM Stulnig - Immunology Letters, 2007 - Elsevier It is now broadly accepted that low-grade chronic inflammation associated with obesity leads
to the onset of insulin resistance and type 2 diabetes mellitus. Obesity-associated inflammation
is characterized by an increased abundance of macrophages in adipose tissue along ... Cited by 34 - Related articles - All 3 versions
GH Goossens - Physiology & Behavior, 2008 - Elsevier Research of the past decade has increased our understanding of the role adipose tissue plays
in health and disease. Adipose tissue is now recognized as a highly active metabolic and endocrine
organ. Adipocytes are of importance in buffering the daily influx of dietary fat and exert ... Cited by 37 - Related articles - All 4 versions
LK Heilbronn, LV Campbell - Current Pharmaceutical Design, 2008 - ingentaconnect.com Abstract: Obesity was first described as a low-grade inflammatory condition more than a decade
ago. However, it is only relatively re- cently that obese individuals have been described with
increased macrophage infiltration of adipose tissue, as well as an increase in the number ... Cited by 36 - Related articles - BL Direct - All 2 versions
G Fruhbeck - Methods Mol Biol, 2008 - Springer Summary As the result of its apparent structural and histological simplicity, adipose tissue
(AT) functions initially were limited to energy storage, insulation, and thermoregulation. Only
decades later was the extraordinarily dynamic role of AT recognized, revealing its ... Cited by 21 - Related articles - All 2 versions
