TS Kern - Exp Diabetes Res, 2007 - hindawi.com Diabetes causes metabolic and physiologic abnormalities in the retina, and these changes suggest
a role for inflammation in the development of diabetic retinopathy. These changes include upregulation
of iNOS, COX-2, ICAM-1, caspase 1, VEGF, and NF-κB, increased production of nitric ... Cited by 34 - Related articles - View as HTML - All 12 versions
- ►diabetesjournals.org JV Busik, S Mohr, MB Grant - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Glucose consumption of HRECs, human retinal pigment
epithelial cells (HRPEs), and human Müller cells (HMCs) under elevated glucose conditions
was measured and compared with cytokine treatment. Production of ROS in HRECs was ... Cited by 16 - Related articles - All 5 versions
C Hernández, R Simó - Expert Opinion in Investigational Drugs, 2007 - informahealthcare.com Proliferative diabetic retinopathy (PDR) demands both more effective and less expensive biologically
based treatments. Our understanding of the pathophysiology of the disease is increasing as
new biochemical pathways are identified. Most reports emphasize proangiogenic stimuli, ... Cited by 10 - Related articles - BL Direct - All 5 versions
JZ Zhang, X Xi, L Gao, TS Kern - Current Eye Research, 2007 - informahealthcare.com Purpose: This study was conducted to examine the effect of angiotensin-converting enzyme
(ACE) inhibitors on the development of early stages of diabetic retinopathy. Methods: Rats were
made diabetic by injection of streptozotocin and treated with the ACE inhibitor captopril ... Cited by 7 - Related articles - BL Direct - All 4 versions
SA Madsen-Bouterse, RA Kowluru - Reviews in Endocrine & Metabolic …, 2008 - Springer Abstract Retinopathy is one of the most severe ocular complications of diabetes and is a leading
cause of acquired blindness in young adults. The cellular components of the retina are highly
coordinated but very susceptible to the hyperglycemic environment. The microvasculature ... Cited by 6 - Related articles - All 2 versions
TS Kern, AJ Barber - The Journal of Physiology, 2008 - pubmedcentral.nih.gov Diabetic retinopathy has long been recognized as a vascular disease that develops in most
patients, and it was believed that the visual dysfunction that develops in some diabetics was
due to the vascular lesions used to characterize the disease. It is becoming increasingly ... Cited by 7 - Related articles - All 7 versions
C Gustavsson, CD Agardh, P Hagert, E Agardh - Retina, 2008 - journals.lww.com Supported by grants from the Lund University, the Järnhardt Foundation, the Malmö University
Hospital Foundation, the Stoltz Foundation, the Foundation for Visually Impaired in Former Malmöhus
Län, the Skane County Council for Research and Development, the Swedish Diabetes ... Cited by 6 - Related articles - BL Direct - All 2 versions
- ►iovs.org RJ Walker, JJ Steinle - Investigative Ophthalmology & Visual Science, 2007 - ARVO RESULTS. Isoproterenol treatment significantly decreased protein levels of iNOS, TNF- , and
IL-1B, in rMC-1 cells cultured in high glucose as early as 1 hour, compared with cells receiving
no treatment. PGE2 content was also reduced after isoproterenol treatment. There were ... Cited by 3 - Related articles - BL Direct - All 2 versions
C Ishikawa, T Tsuda, H Konishi, N Nakagawa, … - Antimicrobial agents …, 2009 - Am Soc Microbiol In addition to their antibiotic effects, tetracyclines have anti-inflammatory action that is often beneficial
in the control of inflammatory skin disorders. In this study, we examined the effects of tetracycline
(TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the ... Cited by 2 - Related articles - All 5 versions
SF Abcouwer, S Shanmugam, PF Gomez, S … - … Ophthalmology & Visual …, 2008 - ARVO RESULTS. IL-1β treatment caused a pronounced decrease in cellular reductive potential.
IL-1β caused depletion of intracellular ATP, loss of mitochondrial transmembrane potential,
caspase-3/7 activation, and LDH release. IL-1β treatment increased rates of glucose ... Cited by 1 - Related articles - All 2 versions
